Maternal inflammatory bowel disease has short and long-term effects on the health of their offspring: A multicenter study in Israel |
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| Institution: | 1. IBD Center, Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;2. Pediatric Gastroenterology Unit of the Department of Pediatrics, Dana Children''s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;3. Department of Gastroenterology and Division of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel;4. IBD Center, Department of Gastroenterology, Hadassah Medical Center—Hebrew University, Jerusalem, Israel;5. IBD Unit, Department of Gastroenterology and Hepatology, Soroka University Hospital, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel;6. Rambam Medical Center, Haifa University, Haifa, Israel;7. Department of Gastroenterology, Meir Medical Center, Kfar Saba, Israel;8. IBD Unit, Department of Gastroenterology and Liver Diseases, Rabin Medical Center, Petah Tikva, Israel;9. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;1. Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria;2. Department of Physiology, All India Institute of Medical Sciences, New Delhi, India;3. Department of Physiology, North DMC Medical College, Hindu Rao Hospital, Delhi 110007, India;1. Department of Genetics and Evolution, Federal University of São Carlos, São Carlos, SP, Brazil;2. Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil;3. Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, BE, Switzerland;4. Chemistry Institute, Paulista State University, Araraquara, SP, Brazil;1. Policy Research Unit in Maternal Health and Care, National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, United Kingdom;2. Faculty of Health and Social Care, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom;1. Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, United Kingdom;2. St. Mary''s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, United Kingdom;1. Gastrointestinal Diseases Research Unit, Department of Medicine, Queen’s University, Kingston, Ontario, Canada;2. Division of Gastroenterology, Hotel Dieu Hospital, 166 Brock Street, Kingston, Ontario K7L 5G2, Canada |
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| Abstract: | BackgroundThere are concerns about the effect of inflammatory bowel diseases (IBD) on fertility, pregnancy and pregnancy outcomes, but no long-term data on the health of offspring born to IBD mothers. The aims were to assess the short- and long-term effects of maternal IBD on the morbidity and development of their offspring.MethodsFemale IBD patients and controls completed questionnaires on their pregnancy outcome, and their offspring's short- and long-term health and development.ResultsIBD and control mothers (159 and 175, respectively) were recruited. Medical data of 412 IBD and 417 control offspring were recorded. IBD mothers had significantly more singleton pregnancies, their offspring's birth weight was significantly lower, and they breastfed significantly less compared to controls (P = 0.028, 0.007, and < 0.0001, respectively). There were significantly more congenital anomalies (mainly limb deformities) among the IBD offspring (P < 0.035). Offspring born post-maternal IBD diagnosis, compared to pre-diagnosis, tended to have more neurodevelopmental problems (e.g., gross motor delay, P = 0.03). IBD was significantly more prevalent in the offspring of IBD mothers, while allergies and atopic dermatitis were more frequent in offspring of control mothers. More offspring of IBD mothers taking medications during pregnancy were born preterm and had lower birth weights compared to offspring of IBD mothers not taking medications during pregnancy. Children of mothers taking steroids had the lowest birth weights, compared to those of IBD mothers taking 5ASAs or immunomodulators.ConclusionsMaternal IBD affects pregnancy and the offspring's immediate and long-term morbidity, specifically, congenital anomalies and neurodevelopmental problems. |
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