Structural Optimization of Indole Derivatives Acting
at Colchicine Binding Site as Potential Anticancer Agents |
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| Authors: | Dong-Jin Hwang Jin Wang Wei Li Duane D. Miller |
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| Affiliation: | Department of Pharmaceutical Sciences, University of Tennessee, HealthScience Center, Memphis, Tennessee 38163, United States |
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| Abstract: | | |
| Keywords: | Colchicine-binding site, tubulin polymerizationinhibitor, prostate cancer, melanoma, antiproliferativeactivity, structure− activity relationship (SAR), multiple drug resistance, liver microsomal stability |
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