奥扎格雷钠注射液对短暂性脑缺血发作患者血液流变性和微循环的影响

目的:观察奥扎格雷钠注射液对短暂性脑缺血发作(TIA)患者异常血液流变性和甲襞微循环的影响。方法:奥扎格雷钠80mg加入5%葡萄糖液250ml中静脉滴注,每天2次,疗程15天。患者于治疗前后分别检测血液流变学指标及综合定量评价甲襞微血管形态、微血流流态,并与川芎嗪注射液治疗组对比分析。结果:TIA患者治疗前全血粘度、血浆粘度、红细胞压积及红细胞聚集指数明显增高,甲襞微循环形态异常,红细胞聚集,出现粒缓流。经两种药物治疗后,上述指标有不同程度改善,尤以奥扎格雷治疗组改善明显,与治疗前比较,差异有显著性意义。结论:奥扎格雷钠注射液能明显改善TIA患者血液流变性异常和微循环障碍,且效果优于川芎嗪注射液。

Effect of Sodium Ozagrel on Blood Rheological Property and Microcirculation of Patients with Transient Ischemic Attack

Objective:To explore the relation change of blood rheological property and the effect of sodium ozagrel on blood rheological property of transient ischemic attack(TIA).Method:56 patients with TIA were treated with sodium ozagrel intravenously for 2 weeks,80 mg every day.The changes of blood rheological property and nail wall microcirculation in all patients before and after treatment were observed.Results:Whole blood viscosity,plasma viscosity,packed cell volume and index of erythrocyte aggregation were obviously increased before treatment,but decreased after treatment.There was statistically significant difference.Conclusion:Sodium ozagrel could improve blood rheological property,nail wall microcirculation and reduce blood viscosity.The measurement of blood rheological property is a major method to study cerebrovascular diseases and evaluate therapeutic effect.