磁性生物陶瓷椎体间融合器的研究

目的 检测由磁性生物陶瓷制作椎体间融合器生物愈合的可行性与稳定性.方法 应用磁性生物陶瓷制作椎体间融合器后,选健康2～4岁山羊9只,平均体重27.8kg,经氯胺酮诱导,气管插管,安氟醚吸入麻醉后,取右下腹腹膜外斜切口,暴露L3与L4椎间隙后,保留前纵韧带,从椎间隙外侧切开纤维环,摘除髓核后,牵引及撑开椎间隙,刮除软骨终板,凿去大部分椎骨表面皮质骨,植入"楔形"磁性生物陶瓷椎体间融合器.结果 9只山羊均成活,术后约8h即可恢复站立,行走;24h后恢复正常行走,进食,但是活动较少,大多数时间处于卧位,休息;3周后情况明显好转,活动恢复至正常.术后6个月,腹部彩色B超检查未见血拴形成,腹部大血管血供正常.定期X线检查,肉眼大体标本观察,光境观察,扫描电镜(SEM)观察,材料与骨实现牢固的"生物愈合".结论 采用磁性生物陶瓷制作椎体间融合器植入体内是可行的.

The experimental study on the magnetic bioceramic implant body cage

Objective To study the effect and stability of the magnetic bioceramic implant body cage in sheep.Methods After the L4/5 intervertebral disc of sheep was removed and replaced with the magnetic bioceramic implant body cage,the recovery of the 9 sheep was observed.The animals were killed at intervals from 1st,3nd and 5th month after operation,and the interface between the prosthesis and bone was examined by naked eye inspection,roentgenography,light and scanning electron microphotography.Results The function of the sheep was recovered rapidly,and bone bonding with the prosthesis was found,but the activity of the sheep could resume normally 3 weeks after the operation.Conclusion The replacement with the magnetic bioceramic implant body cage after removal of the intervertebral disc is effective and stable,and the biological fixation could be achieved with the bone ingrowth.