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Serotonin transporter availability in the midbrain and perceived social support in healthy volunteers
Authors:Hsiang Yu Huang  I Hui Lee  Kao Chin Chen  Shih-Hsien Lin  Tzung Lieh Yeh  Po See Chen  Nan-Tsing Chiu  We Jen Yao  Chia-Chieh Chen  Mei-Hsiu Liao  Yen Kuang Yang
Affiliation:1. Department of Psychiatry, Tainan Municipal Hospital, Tainan, Taiwan;2. Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;3. Addiction Research Center, National Cheng Kung University, Tainan, Taiwan;4. Department of Psychiatry, National Cheng Kung University, Dou-Liou Branch, Yunlin, Taiwan;5. Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan;6. Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, Taoyuan, Taiwan
Abstract:

Objective

Serotonin modulates human behavior and emotion. Recent evidence implies that a higher level of serotonergic activity could be associated with a higher level of perceived social support. This study aimed to examine the correlation between serotonin transporter (SERT) availability and perceived social support scores in healthy volunteers.

Methods

111 healthy participants, 50 males and 61 females, were enrolled from the community and completed the Measurement of Support Function questionnaire. Single photon emission computed tomography (SPECT) with [123I] ADAM was performed to examine SERT availability.

Results

Perceived social support was positively correlated with SERT availability (Spearman's ρ = 0.29, p < 0.01; χ2 = 7.57, p < 0.01), particularly in males (Spearman's ρ = 0.37, p < 0 .01; χ2 = 11.77, p < 0.01). Censored regressions indicated that these associations are not influenced by a ceiling effect and remained significant after controlling the effect of age.

Conclusions

This result confirmed the correlation between perceived social support and central serotonergic activity. However, this correlation was present only in males.
Keywords:Gender difference   MSF   Serotonin system   SERT availability   Social support   SPECT
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