Physical Activity,Sedentary Behavior,and Risk of Coronavirus Disease 2019 |
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| Institution: | 1. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;2. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;3. Simmons University, Boston, Mass;4. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Mass;5. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Mass;6. Division of Women''s Health, Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, Mass;7. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Mass;8. Channing Division of Network Medicine, Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, Mass;9. Samuel Oschin Comprehensive Cancer Center at Cedars-Sinai, Los Angeles, Calif;10. Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, Calif;11. Department of Population Science, American Cancer Society, Kennesaw, Ga;12. Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla;13. Moores Cancer Center, University of California, San Diego, La Jolla |
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| Abstract: | IntroductionData on the associations of prepandemic physical activity and sedentary behavior with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) severity, particularly milder illness, have been limited.MethodsWe used data from 43,913 participants within the Nurses’ Health Study II and Health Professionals Follow-Up Study who responded to periodic COVID-related surveys from May 2020 through March 2021. History of physical activity from the prepandemic period was assessed as the metabolic equivalents of task (MET)-hours per week of various activities of different intensity and sedentary behavior assessed from reports of time spent sitting from questionnaires completed 2016-2017. Multivariable logistic regression models were fitted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for risk of SARS-CoV-2 infection and COVID-19 severity, as well as predicted COVID-19 defined using a validated symptom-based algorithm.ResultsHigher levels of prepandemic physical activity were associated with a lower risk for SARS-CoV-2 infection. Compared to participants with <3 MET-hours per week, the multivariable-adjusted OR was 0.86 (95% CI: 0.74, 0.99; P trend =.07) for those with ≥27 MET-hours per week. Higher physical activity levels were also associated with lower risk of symptomatic SARS-CoV-2 infection (OR: 0.84; 95% CI: 0.72, 0.99; P trend = .05) and predicted COVID-19 (OR: 0.87; 95% CI: 0.78, 0.97; P trend = .01). Longer time sitting at home watching TV (OR: 0.85; 95% CI: 0.73, 0.97) or for other tasks (OR: 0.78; 95% CI: 0.66, 0.92) was associated with a lower risk of SARS-CoV-2 infection.ConclusionsOur findings support a protective association between prepandemic physical activity and lower risk and severity of COVID-19. |
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