A Pilot Study: Transcriptional Profiling,Functional Analysis,and Organoid Modeling of Intestinal Mucosa in Hirschsprung Disease |
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| Affiliation: | 1. University of Michigan, Department of Surgery, Division of Pediatric Surgery, 1540 East Hospital Drive, Ann Arbor, MI, 48109-4211, USA;2. University of Michigan, Department of Internal Medicine, Division of Infectious Disease, Ann Arbor, MI, 48109, USA;3. University of Michigan, Department of Internal Medicine, Division of Gastroenterology, Ann Arbor, MI, 48109, USA;4. University of Michigan Medical School, Department of Cell and Developmental Biology, Ann Arbor, MI, 48109, USA;5. University of Michigan Medical School, Department of Biomedical Engineering Medicine, Ann Arbor, MI, 48109, USA;6. University of Michigan, Department of Microbiology & Immunology, Ann Arbor, MI, 48109, USA |
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| Keywords: | Hirschsprung RNA sequencing Organoid Inflammation Ganglion Epithelium Enterocolitis DEG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Differential gene expression FDR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" False discovery rate HAEC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Hirschsprung Associated Enterocolitis HSCR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" Hirschsprung Disease HD-G" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" Ganglionic Tissue HD-A" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" Aganglionic Tissue KEGG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" Kyoto Encyclopedia of Genes and Genomes PCA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" Principal component analysis qPCR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" Quantitative Polymerase Chain Reaction RNASeq" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" RNA Sequencing TEER" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" Transepithelial electric resistance |
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