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Synthesis and in silico studies of some new pyrrolidine derivatives and their biological evaluation for analgesic and anti-inflammatory activity
Affiliation:1. Chemistry Department, Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Sciences Faculty, Badji Mokhtar - Annaba University, Box 12, Annaba 23000, Algeria;2. Laboratoire PEIRENE, EA7500, Universite de Limoges, 123 avenue Albert Thomas, Limoges Cedex 87000, France;3. Unité de Recherche de Chimie de L''Environnement et Moléculaire Structurale, Université des Frères Mentouri, Constantine 25000, Algéria;4. Small Molecules for Biological Targets Team, Centre de recherche en cancerologie de Lyon, Centre Leon Berard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, University of Lyon, Lyon 69373, France;5. Department of Chemistry, Laboratory of Applied and Environmental Chemistry, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco;6. Faculty of Sciences, CEISAM laboratory, University of Nantes, UMR CNRS 6230, 2, rue de la Houssinière – BP, 92208-44322, Nantes Cedex 3, France;7. Laboratory of therapeutic chemistry of Hospitalo-University Center Benflis Touhami Batna, Algeria;8. Département des Sciences de La Matiére, Université Larbi Ben M''Hidi, 04000, Oum El Bouaghi, Algeria
Abstract:
Keywords:Pyrrolidine  Molecular docking  Analgesic activity  Anti-inflammatory activity  Pyrrolidine  Amarrage moléculaire  Activité analgésique  Activité anti-inflammatoire
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