Analysis of clinical features of primary empty sella |
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| Affiliation: | 1. Department of Endocrinology, Wuhan Fourth Hospital, 430000 Wuhan, China;2. Department of Endocrinology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China;3. Department of Endocrinology, Huangzhou District People''s Hospital, Huanggang, 438000 Hubei, China;1. Service d’endocrinologie diabétologie et maladies métaboliques, CHRU de Brest, boulevard Tanguy Prigent, 29609 Brest cedex, France;2. Service de médecine nucléaire, Hôtel Dieu, CHU de Nantes, 1, place Alexis Ricordeau, 44093 Nantes, France;3. Fédération d’endocrinologie, groupement hospitalier Est, hospices civils de Lyon, 28, avenue du Doyen Lépine 69677 Bron Cedex, France;4. Inserm U1290, université Claude Bernard Lyon 1, Lyon, France;5. Sorbonne université, service de médecine nucléaire, hôpital Pitié-Salpêtrière, AP–HP, 47-83, boulevard de l’Hôpital, 75651 Paris Cedex 13, France;6. Inserm U970, Paris, France;1. Erciyes University Medical School Department of Internal Medicine, Kayseri, Turkey;2. Erciyes University Medical School Department of Endocrinology, Kayseri, Turkey;3. Yeditepe University Medical School Department of Endocrinology, İstanbul, Turkey;1. Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, 6500 HB Nijmegen, The Netherlands;2. Department of Radiology (C2-P-117), Section of Nuclear Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands;3. Biomedical Photonic Imaging Group, University of Twente, 7500 AE Enschede, The Netherlands;4. Radiation Science & Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands;5. Department of Radiology and Nuclear Medicine, Rijnstate, Hospital, 6800 TA Arnhem, The Netherlands;6. Department of Biomedical Sciences and Humanitas Clinical and Research Centre, Department of Nuclear Medicine, Humanitas University, via Rita Levi Montalcini 4, 20072 Pieve Emanuele (MI), Italy;1. Department of Endocrinology and Metabolism, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey;2. Department of Radiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey;3. Department of General Surgery, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey;1. Department of Endocrinology, Seth G S Medical College and KEM Hospital, 103, 1st floor, OPD building, KEM Hospital Campus, Parel, Mumbai, Maharashtra 400012, India;2. Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India;3. Jawaharlal Nehru Medical College, Karnataka, India;4. Department of Nephrology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India |
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| Abstract: | ObjectiveA retrospective analysis of clinical data of 60 patients with primary empty sella (PES) was conducted to further improve the understanding of the disease.MethodsThe clinical data of 60 patients diagnosed with PES admitted to the Department of Endocrinology of Wuhan Union Hospital for different reasons from January 2000 to September 2018 were analyzed.ResultsThe 60 cases comprised 22 (36.67%) male and 38 (63.33%) female patients, for a male-to-female ratio of 1:1.73. There was predominance of 50–59 year-olds and women with multiple pregnancies. Of the 60 patients, 41.67% showed fatigue, 26.67% dizziness and headache, 21.67% nausea and vomiting, 18.33% anorexia, and 6.67% visual impairment and other symptoms. Twenty-seven patients (45.0%) had normal pituitary function, and 33 (55.0%) had hypopituitarism. Complete PES was more prone to result in hypopituitarism than partial PES. Men with PES were more likely to have hypopituitarism than women.ConclusionThe incidence of PES was significantly higher in women than in men; PES was common in middle-aged and older women with multiple pregnancies. Symptoms were diverse and clinical manifestations may lack specificity compared to other diseases and need to be differentiated. About half of PES patients may develop hypopituitarism. Therefore, for patients with empty sella detected on magnetic resonance imaging (MRI) with or without clinical symptoms, the pituitary function should be thoroughly and promptly evaluated. |
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| Keywords: | Pituitary Primary empty sella Clinical features Hypopituitarism |
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