Role of leptin and its receptors in the pathogenesis of thyroid cancer |
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| Authors: | Uddin Shahab Hussain Azhar R Siraj Abdul K Khan Omar S Bavi Prashant P Al-Kuraya Khawla S |
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| Affiliation: | Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia. Shahab@kfshrc.edu.sa |
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| Abstract: | Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described. |
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| Keywords: | Leptin leptin receptors sinaling pathways papillary thyroid carcinoma |
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