| 慢性重型病毒性肝炎患者血浆和尿液脂质过氧化物水平及其意义 |
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| 引用本文： | 何长伦,李奇芬,李平.慢性重型病毒性肝炎患者血浆和尿液脂质过氧化物水平及其意义[J].安徽医科大学学报,1991(3). |
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| 作者姓名： | 何长伦 李奇芬 李平 |
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| 作者单位： | 解放军八一医院传染科，第三军医大学西南医院传染科，第三军医大学西南医院传染科 校友 |
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| 摘 要： | 采用荧光法检测38例慢性重型病毒性肝炎(慢重肝)、22例急性肝炎和20名正常人血浆和尿液脂质过氧化物(LPO)含量。同时用放免法检测慢重肝血浆环核苷酸、前列环素(PGI_2)和血栓素A发_2(TXA_2、含量,并与血浆LPO作相关分析。结果发现:①慢重肝血浆和尿液LPO含量较急性肝炎和正常人均非常显著升高(P均<0.01)。②血浆LPO与尿液LPO及血浆TXA_2呈正相关,与血浆cAMP及PGI_2呈负相关。提示脂质过氧化在慢重肝的肝损害中可能起重要作用。
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| 关 键 词： | 肝炎 病毒性 人 慢性病 过氧化脂质类 前列腺素X类 血栓素A_2 |
A preliminary study on plasma and urinary LPO levels in patients with chronic severe viral hepatitis |
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| He Changlun et al.A preliminary study on plasma and urinary LPO levels in patients with chronic severe viral hepatitis[J].Acta Universitis Medicinalis Anhui,1991(3). |
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| Authors: | He Changlun |
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| Institution: | He Changlun et al |
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| Abstract: | The plasma and urinary lipid peroxides (LPO)levels were measured by fluorometric assay in 38 patients with chronic severe viral hepatitis(CSVH), 22 patients with acute hepatitis (AH)and 20 healthy controls. The levels of plasma cyclic nucleotide, prostacyclin(PGI_2) and thromboxane A_2(TXA_2) were simultaneously meassured by RIA in patients with CSVH. The results showed that: 1. In comparision with AH and controls, the plasma and urinary LPO levels in patients with CSVH were significantly elevated(P<0.01). 2. In patients with CSVH, the plasma LPO levels were positively related to plasma TXA_2 and urinary LPO, and negatively related to PGI_2 and cAMP. The important role of lipid peroxidation in hepatic injury were discussed. |
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| Keywords: | hepatitis viral human chronic disease lipid peroxides(LPO) prostaglandins x thromboxane A_2(TXA_2) |
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