Induction of chromosmal aberrations in the syrian hamster by insecticides tested in vivo |
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Authors: | Alina Dzwonkowska Henryk Hübner |
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Institution: | (1) Institute of Physiology and Cytology, Laboratory of Plant Cytology and Cytochemistry, University of ód , 90-237 ód , 12/16 Banacha, Poland |
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Abstract: | The insecticides demeton, dimetoat, dichlorovos, endosulfan, trichlorofon, carbaryl, lindane, methoxychlor, propoxur and malathion were examined for their ability to induce chromosomal aberrations in the bone marrow cells of the Syrian hamster (Mesocricetus auratus) treated in vivo. Mutagenicity of commercial preparations was examined at four doses: LD50; 1/2, 1/5 and 1/10 LD50. The positive control was an IP injection of cyclophosphamide to hamsters at a dose of 40 mg/kg body wt. Demeton, dichlorovos and endosulfan gave positive results. Malathion, dimethoate and the mixture of methoxychlor and propoxur were weakly clastogenic; at some doses these compounds induced statistically significant increases in the number of aberrations. Trichlorfon and the mixture of carbaryl and lindane were negative in this test.This work was supported by the Polish Academy of Sciences within the projet 09.7.3.4.3 |
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Keywords: | Insecticides Cyclophosphamide Demeton Dimethoate Dichlorvos Endosulfan Trichlorfon Carbaryl Lindane Methoxychlor Propoxur Malathion Chromosomal aberrations Syrian hamster |
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