运动病大鼠血浆降钙素基因相关肽含量的变化

目的: 探讨降钙素基因相关肽(CGRP)在运动病发病过程中的作用. 方法: 第1组30只大鼠按随机数字法分为4个实验组和1个对照组,实验组动物给予30 min旋转运动刺激,然后各自测4个实验组动物旋转运动刺激后20 min, 6 h, 1 d, 3 d以及对照组动物血浆CGRP含量;第2组20只大鼠先给予15 min的旋转运动刺激,根据刺激前后24 h糖精水饮用量的变化分为运动病敏感组和不敏感组,然后测两组动物旋转运动刺激15 min后血浆CGRP含量. 结果: 第1组动物,实验组动物旋转运动刺激30 min后各时间点大鼠血浆CGRP含量和对照组差异没有显著性意义(F=1.105, P=0.893);第2组动物,运动病敏感组与运动病不敏感组相比,旋转运动刺激15 min后血浆CGRP含量差异无显著性意义(P=0.704). 结论: 血浆CGRP在大鼠运动病发病机制中没有发挥作用;大脑中枢和前庭终器中CGRP是否参与了运动病的发病尚需深入研究.

Effect of rotatory stimulation on plasma level of calcitonin gene-related peptide in rats

AIM: To explore the relation between calcitonin gene-related peptide(CGRP) and motion sickness(MS) in rats.METHODS: A group of 30 rats were subdivided into 4 experimental groups and a control group with a random number table.The rats of experimental groups were treated with rotatory stimulation for 30 min.Then the plasma levels of CGRP in 4 experimental groups were measured respectively 20 min,6 h,1 and 3 d(after) the stimulation.According to the changes of rat's intake of saccharin solution before and 24 h after rotatory stimulation for 15 min.Another group of 20 rats were subdivided into a group sensitive to MS and a group insensitive to MS,then the plasma levels of CGRP in the 20 rats were measured 20 min after rotatory stimulation for 15 min.RESULTS: There was no significant difference in the plasma levels of CGRP at different time points after rotatory stimulation in the first group(F=1.105,P=0.893);there was no significant difference in the plasma levels of CGRP between the group sensitive to MS and the group insensitive to MS(P=(0.704).) CONCLUSION: The CGRP in blood plasma doesn't play an role in the pathogenesis of MS.