辛伐他汀调脂干预治疗急性冠脉综合征病人血浆CRP及NO水平的影响

目的探讨辛伐他汀对急性冠状动脉综合征(ACS)病人血浆C-反应蛋白(CRP)及血脂干预的作用。方法符合ACS诊断标准的病人73例,随机分成辛伐他汀组(治疗组)和常规组(对照组),分别在治疗前和治疗28d后,清晨空腹抽静脉血5mL,应用速率散射免疫比浊法测定血浆CRP,同时测定血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、一氧化氮(NO)等水平。结果治疗组CRP,LDL,TC,TG较对照组明显下降(P<0.05或P<0.01),而NO水平明显升高(P<0.01)。结论辛伐他汀调脂干预治疗,能够降低ACS应激反应,减轻冠状动脉粥样硬化的炎症反应和脂质过氧化损伤,改善冠状动脉内皮细胞功能。

Effects of Simvastatin On Plasma CRP and NO in the Patients with Acute Coronary Syndrome

Objective To investigate the effects of simvastatin on plasma CRP in the patients(pts) with acute coronary syndrome(ACS).Methods Seventy-tree pts diagnosed as ACS were randomly divided into simvastatin treatment group and control group.CRP was detected by velocity scatter immune turbidimetr,serum low density lipoprotein(LDL),total cholesterol(TC),triglyceride(TG) and nitric oxide(NO) were detected.Results The content of CRP and LDL,TC,TG in simvastatin treatment group were lower than that in control group(P<0.05 or P<0.01) and the level of NO increased significantly(P<0.01).Conclusion Simvastatin could prevent the inflammatory response and the damage of lipid peroxidation of coronary atherosclerotic lesions and improve the function of coronary endothelial cell to reduce occurrence of ACS.