Control of prostate cancer by transrectal HIFU in 227 patients |
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Authors: | Poissonnier Laura Chapelon Jean-Yves Rouvière Olivier Curiel Laura Bouvier Raymonde Martin Xavier Dubernard Jean Michel Gelet Albert |
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Institution: | Urology, Radiology and Pathology Department, Edouard Herriot Hospital, Lyon, France. |
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Abstract: | PURPOSE: To evaluate the results of high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer with reference to disease-related prognostic factors. MATERIALS AND METHODS: Patients with T1-2 localized prostate cancers, prostate specific antigen (PSA) 1 ng/ml with three consecutive rises. RESULTS: The study included 227 patients. Mean follow-up was 27+/-20 months (12-121 months). Eighty-six percent had negative control biopsies. Median nadir PSA was 0.10 ng/ml. The actuarial 5-year disease-free survival rate (DFSR), combining pathologic and biochemical outcomes, was 66%. DFSR showed a significant decrease when stratified according to initial PSA level: 90% with PSA
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Keywords: | Ultrasound surgery High-intensity focused ultrasound Localized prostate cancer |
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