| 肥胖症全基因组关联分析研究进展 |
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| 引用本文： | 石娟,洪洁.肥胖症全基因组关联分析研究进展[J].国外医学：内科学分册,2009,36(9):544-547. |
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| 作者姓名： | 石娟 洪洁 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院内分泌代谢病科 上海市内分泌代谢病临床中心,上海200025 |
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| 摘 要： | 肥胖症的产生是由遗传和各种环境因素相互作用的结果。肥胖易感基因可以为肥胖症机制的研究提供重要的视角。全基因组关联分析（GWAS）的出现为研究肥胖易感基因提供了重要的途径。GWAS近来已经发现与肥胖强烈相关的新的遗传学因素，如脂肪含量和肥胖相关基因（FrO），胰岛素诱导基因2（INSIG2），血小板型磷酸果糖激酶（PFKP）等。目前，通过GWAS发现的一些肥胖易感基因还存在着争议，有待更多具有统计效能的重复性试验来证实。
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| 关 键 词： | 肥胖 全基因组关联分析 基因多态性 |
Research progress on obesity by genome-wide association study |
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| SHI Juan,HONG Jie.Research progress on obesity by genome-wide association study[J].Foreign Medical Sciences(Section of Internal Medicine),2009,36(9):544-547. |
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| Authors: | SHI Juan HONG Jie |
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| Institution: | SHI Juan,HONG Jie. Department of Endocrinology and Metabolism,Shanghai Clinical Center for Endocrine and Metabolic Diseases,Shanghai Institute of Endocrinology and Metabolism,Ruijin Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China |
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| Abstract: | Obesity is the result of the interaction between genetic and environmental factors.Susceptive genes of obesity can provide important insights into the mechanism underlying this condition.The advent of genome-wide association study(GWAS)provides an important approach for studying susceptive genes of obesity.GWAS has recently identified some novel genetic factors with strong associations with obesity,such as FTO(the fat mass and obesity associated gene),INSIG2(insulin induced gene 2),PFKP(platelet type phosph... |
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| Keywords: | Obesity Genome-wide association study Gene polymorphism |
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