| 心痛贴抗心肌缺血的实验研究 |
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| 引用本文： | 张芳林 蒋丽萍 欧阳晃平 陈晓媛 冯高闳. 心痛贴抗心肌缺血的实验研究[J]. 江西医学院学报, 2002, 42(6): 14-15,18 |
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| 作者姓名： | 张芳林 蒋丽萍 欧阳晃平 陈晓媛 冯高闳 |
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| 作者单位： | [1]江西省洪都中医院内科，江西南昌３３００００ [2]江西医学院药理教研宣，江西南昌３３０００６ |
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| 摘 要： | 目的：观察心痛贴经皮给药治疗心肌缺血的疗效。方法:iv 1.0μ／ｋｇ垂体后叶素致ＳＤ大鼠心肌缺血损伤，观察经皮给药后缺血心肌的心电固变化；结扎ＳＤ大鼠冠脉左前降支致心肌缺血，用０．５％硝基四氮唑蓝（Ｎ—ＢＴ）染色，把末染色的梗塞心肌剪下用滤纸吸干称重，计算梗塞心肌占心室重量的百分比；ＳＣ ８ｍｇ／ｋｇ ＩＳＯ致ＳＤ大鼠心肌损伤，测血清及心肌ＣＰＫ。结果：心痛贴心前区贴敷４．４９ｇ／ｋｇ、８．９８ｇ／ｋｇ＾２能明显抑制ｉｖ １．０μ／ｋｇ垂体后叶家所致缺血心肌的心电固变化；降低ＳＣ ８ｍｇ／ｋｇ ＩＳＯ所致损伤心肌血清ＣＰＫ的水平；ｉＶ ３．４５ｇ／ｋｇ心痛贴能明显缩小ＳＤ大鼠冠脉血管结扎所致心肌梗塞面积。结论：心痛贴经皮给药可产生抗心肌缺血作用。
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| 关 键 词： | 中药验方 心痛贴 抗心肌缺血 实验研究 治疗 垂体后叶素 |
| 文章编号： | 1000-2294(2002)06-0014-02 |
Experimental Study of Therapeutic Efficacy of Heartache Sticks in Myocardial Ischemia |
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| ZHANG Fang lin ,JIANG Li ping ,OU Yang Huang ping ,CHEN Xiao yuan ,FENG Gao hong. Experimental Study of Therapeutic Efficacy of Heartache Sticks in Myocardial Ischemia[J]. Acta Academiae Medicinae Jiangxi, 2002, 42(6): 14-15,18 |
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| Authors: | ZHANG Fang lin JIANG Li ping OU Yang Huang ping CHEN Xiao yuan FENG Gao hong |
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| Affiliation: | ZHANG Fang lin 1,JIANG Li ping 1,OU Yang Huang ping 2,CHEN Xiao yuan 1,FENG Gao hong 1 |
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| Abstract: | Objective:To observe the effect of the heartache sticks on myocardial ischemia. Methods: Myocardial ischemia model of rats was induced by iv 1.0 U/kg pituitrin,SC 8 mg/kg ISO,and ligation of the anterior branch of the left coronary.Results:The heartache sticks 4.49 g/kg and 8.98 g/kg both obviously repressed the electrocardiogram variety induced by iv 1.0 U/kg pituitrin and lower the CPK level induced by SC 8 mg/kg ISO.Iv 3.45 g/kg of heartache sticks obviously contracted the cardiac infarction area induced by ligation of the anterior branch of the left coronary of SD rats.Conclusion: The heart sticks have function of anti-myocardial ischemia. |
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| Keywords: | the heartache sticks pituitrin isoprenaline myocardial ischemia CPK |
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