A case of mixed lineage acute non-lymphocytic leukemia with t(5;12)(p13;p13) |
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Authors: | S Shimizu Y Tsunematsu J Fujimoto S Mizutani Y Kaneko |
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Affiliation: | Department of Pediatrics, Keiyu General Hospital, Yokohama. |
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Abstract: | A two-year-old boy had mixed lineage acute non-lymphocytic leukemia (ANLL) with a 46,XY, t(5;12)(p13;p13) karyotype. He was admitted to the hospital with fever and petechiae. Morphological and cytochemical characteristics showed the blasts to meet the standard French-American-British criteria for M1, but surface marker analysis showed the blasts to express both myeloid (CD33: 91.3%) and T-cell (CD2: 82.3%, CD7: 97.9%) antigens. The boy was treated with an ANLL protocol, and successfully brought to a remission which has continued for more than 30 months. |
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Keywords: | Chromosome abnormality t(5 12)(p13 p13) Mixed lineage leukemia CD2+ ANLL |
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