| nm23基因在涎腺腺样囊性癌中的表达及其与肺转移的关系 |
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| 引用本文： | 史宏男,何荣根,邱蔚六,张伟国,徐宏波.nm23基因在涎腺腺样囊性癌中的表达及其与肺转移的关系[J].中华口腔医学杂志,1997(1). |
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| 作者姓名： | 史宏男 何荣根 邱蔚六 张伟国 徐宏波 |
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| 作者单位： | 上海第二医科大学口腔医学院，上海铁道大学附属甘泉医院口腔颌面外科 |
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| 摘 要： | 为探讨肿瘤转移抑制基因ｎｍ２３与涎腺腺样囊性癌（ａｄｅｎｏｉｄｃｙｓｔｉｃｃａｒｃｉｎｏｍａ，ＡＣＣ）的关系，应用ＬＳＡＢ免疫组化染色方法，研究ｎｍ２３表达产物二磷酸核苷激酶（ｎｕｃｌｅｏｓｉｄｅｄｉｐｈｏｓｐｈａｔｅｋｉ－ｎａｓｅ，ＮＤＰＫ）在ＡＣＣ中的表达。结果：ＮＤＰＫ／ｎｍ２３在ＡＣＣ中有较高表达，阳性率为６４．０％（１６／２５）；其中，有肺转移者阳性率为１２．５％（１／８），无肺转移者阳性率为８８．２％（１５／１７），差异有极显著性（Ｐ＜０．０１）；ＮＤＰＫ表达与临床分期有关，分期越高，阳性率越低，差异有显著性（Ｐ＜０．０５），与病理分型差异无显著性（Ｐ＞０．０５）。结论：ｎｍ２３基因在人ＡＣＣ肺转移过程中起到抑制转移的作用，可作为临床颈侧ＡＣＣ患者转移和预后的指标。
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| 关 键 词： | 癌.腺样囊性 基因.抑制.肿瘤 免疫组织化学 nm23基因 |
nm23 expression and its correlation with lung metastasis in human salivary adenoid cystic carcinoma |
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| Shi Hongnan,He Ronggen,Qiu Weiliu,et al..nm23 expression and its correlation with lung metastasis in human salivary adenoid cystic carcinoma[J].Chinese Journal of Stomatology,1997(1). |
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| Authors: | Shi Hongnan He Ronggen Qiu Weiliu |
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| Institution: | Shi Hongnan,He Ronggen,Qiu Weiliu,et al. School of Stomatology,Shanghai Second Medical University,Shanghai 200011 |
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| Abstract: | The nm23 gene products, nucleoside diphosphate kinase (NDPK), expression in salivary adenoid cystic carcinoma (ACC) was evaluted by using LSAB immunohistochemical method. Of 25 cases tested, 16 (64.0%) showed positive staining, in which, higher incidence of positive staining was found in ACC without lung metastasis (88.2%, 15/17) than in that with lung metastasis (12.5%, 1/8; P <0.01). Expression of NDPK/nm23 was correlated with the P TNM pattern ( P <0 05), otherwise it was not correlated with pathologic types ( P >0 05). The result suggest that the nm23/NDPK may play a role in suppressing the metastatic potential in ACC. |
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| Keywords: | Carcinoma adenoid cystic Gene suppressor tumor Immunohistochemistry nm23 gene |
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