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动脉化疗栓塞联合CIK细胞过继免疫治疗对中晚期肝癌患者免疫功能的影响
引用本文:杨茂,郭志,司同国,邢文阁,刘方,李保国,于海鹏. 动脉化疗栓塞联合CIK细胞过继免疫治疗对中晚期肝癌患者免疫功能的影响[J]. 介入放射学杂志, 2011, 20(2): 116-119
作者姓名:杨茂  郭志  司同国  邢文阁  刘方  李保国  于海鹏
作者单位:天津市肿瘤防治重点实验室,天津医科大学附属天津肿瘤医院肿瘤介入治疗科,300060
基金项目:国家科技支撑计划课题资助项目(编号:2007BAI05B06)
摘    要:目的 分析肝动脉化疗栓塞(TACE)联合细胞因子诱导的杀伤细胞(CIK)过继免疫治疗对中晚期肝癌患者外周血T淋巴细胞亚群及NK细胞的影响及临床意义.方法 回顾天津肿瘤医院136例中晚期原发性肝癌患者(均为TACE术后,经影像学检查显示无远处转移)资料,依据治疗方式分为两组:TACE联合CIK治疗67例为研究组,单纯TA...

关 键 词:原发性肝细胞癌  细胞因子诱导杀伤细胞  T淋巴细胞亚群  NK细胞  CD4+CD25+调节T细胞(Treg细胞)

Influence of transcatheter arterial chemoembolization combined with cytokine-induced killer cell on the immune function in patients with advanced primary hepatocellular carcinoma
YANG Mao,GUO Zhi,SI Tong-guo,XING Wen-ge,LIU Fang,LI Bao-guo,YU Hai-peng. Influence of transcatheter arterial chemoembolization combined with cytokine-induced killer cell on the immune function in patients with advanced primary hepatocellular carcinoma[J]. Journal of Interventional Radiology, 2011, 20(2): 116-119
Authors:YANG Mao  GUO Zhi  SI Tong-guo  XING Wen-ge  LIU Fang  LI Bao-guo  YU Hai-peng
Affiliation:YANG Mao,GUO Zhi,SI Tong-guo,XING Wen-ge,LIU Fang,LI Bao-guo,YU Hai-peng.Department of Interventional Therapy,Cancer Institute and Affiliated Hospital of Tianjin Medical University,Tianjin 300060,China.
Abstract:Objective To investigate the influence of TACE and autologous cytokine-induced killer(CIK) cells on the peripheral T lymphocyte subsets and native killer cell in patients with advanced primary hepatocellular carcinoma(HCC).Methods A total of 136 patients with unresectable HCC were divided into study group(n = 67,patients were treated with CIK cell therapy after TACE),and control group(n = 69,patients were treated with TACE only).The serum levels of AFP,T lymphocyte subsets and native killer(NK) cell in peri...
Keywords:hepatocellular carcinoma  cytokine-induced killer cell  T lymphocyte subset  native killer cell  CD4 CD25 Treg cells  
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