ＦＯＬＦＯＸ６方案联合腹部内生场热疗治疗晚期大肠癌的临床研究

目的　评价ＦＯＬＦＯＸ６方案联合腹部内生场热疗治疗晚期大肠癌的疗效和不良反应。方法　对照组３９例采用ＦＯＬＦＯＸ６方案：奥沙利铂１００ｍｇ／ｍ２静滴２小时，第１天；亚叶酸钙（ＣＦ）２００ｍｇ／ｍ２静滴２小时，第１天；氟尿嘧啶（５-ＦＵ）４００ｍｇ／ｍ２静推，第１天，然后总量２４００ｍｇ／ｍ２持续静滴４６小时；每２周重复１次。试验组３９例采用ＦＯＬＦＯＸ６方案化疗的同时（剂量和方法同对照组），每周期第１天（５-ＦＵ静滴后１小时）、第８天分别进行腹部内生场热疗１小时。４周期治疗结束后评价疗效和毒副反应。结果　试验组有效率（ＣＲ＋ＰＲ）为５６４１％，中位肿瘤进展时间（ＴＴＰ）为９.５个月；对照组有效率为４１.０３％，中位ＴＴＰ为８.６个月，试验组略优于对照组，但两组差异无统计学意义（Ｐ值分别为０.１７４和０.８１２）。试验组神经系统毒性较对照组明显减轻，尤其是肢端感觉异常及面部感觉异常，两组差异有统计学意义（Ｐ值分别为０.０２３和０.０３９）。结论　ＦＯＬＦＯＸ６方案联合腹部内生场热疗治疗晚期大肠癌的疗效好，毒副作用少。

Clinical study on the treatment of advanced colorectal cancer with FOLFOX 6 regimen combined with abdominal endogeny heat therapy

Objective To evaluate the effect and adverse reaction of FOLFOX 6 regimen combined with abdominal endogeny heat therapy on advanced colorectal cancer.Methods Thirty-nine cases in control group were treated by FOLFOX 6 regimen: oxaliplatin 85mg/m2 iv over 2h on d1;leucovorin 200mg/m2 iv over 2h on d1;fluorouracil(5-FU) 400mg/m2 iv bolus on d1,and then followed by total 2400mg/m2 over 46h continuous infusion.Two weeks was a cycle.Thirty-nine cases in treatment group were treated by FOLFOX 6 regimen(the same a...