| 肿瘤的化学治疗:N-羟乙基-异喹啉-3-羧酸内酯衍生物的合成 |
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| 引用本文： | 严晓明,翁尊尧. 肿瘤的化学治疗:N-羟乙基-异喹啉-3-羧酸内酯衍生物的合成[J]. 药学学报, 1985, 20(4): 312-315 |
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| 作者姓名： | 严晓明 翁尊尧 |
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| 作者单位： | 中国科学院上海药物研究所(严晓明)，中国科学院上海药物研究所(翁尊尧) |
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| 摘 要： | Wick曾报道多巴甲酯(1)对小鼠L_(1210),P_(388)淋巴白血病和B_(16)黑色素瘤有明显抑制作用,并能选择性地抑制B_(16)细胞DNA的合成和黑色素的形成。3,4-二羟基苯乙胺(2)也具有和化合物(1)相似的抗肿瘤作用。
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| 关 键 词： | 肿瘤化疗 N-羟乙基-异喹啉-3-羧酸内酯 |
| 收稿时间： | 1984-05-21 |
TUMOR CHEMOTHERAPY: SYNTHESIS OF N-HYDROXYETHYL-ISOQUINOLINE-3-CARBOXYLIC LACTONE DERIVATIVES |
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| YAN Xiao-Ming and WENG Zun-Yao. TUMOR CHEMOTHERAPY: SYNTHESIS OF N-HYDROXYETHYL-ISOQUINOLINE-3-CARBOXYLIC LACTONE DERIVATIVES[J]. Acta pharmaceutica Sinica, 1985, 20(4): 312-315 |
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| Authors: | YAN Xiao-Ming and WENG Zun-Yao |
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| Abstract: | It was reported that dopa methyl ester exhibited pronounced inhibitory action against various kinds of animal tumors. Many lactonc compounds such as camptothecin, bruceantin arc also characterized by its action against animal tumors.In the present paper some dopa ester analogues had been synthesized, in which lactone was introduced to replace the ester groups and isoquinolin ring was used to replace dopamine structure.The above mentioned compounds were screened against S-180 and EAC in mice, but none showed marked inhibitory activity. |
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| Keywords: | Tumor chemotherapy N-hydroxyethyl-isoquinoline-3-carboxylic lactone |
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