| MMP-9及其抑制剂TIMP-2在非小细胞肺癌中的表达与病理特征的相关性 |
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| 引用本文： | 郑先杰,孙明飞,张双林,宋言峥,张筱扬.MMP-9及其抑制剂TIMP-2在非小细胞肺癌中的表达与病理特征的相关性[J].河南大学学报(医学版),2012(4):265-267. |
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| 作者姓名： | 郑先杰 孙明飞 张双林 宋言峥 张筱扬 |
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| 作者单位： | 河南大学第一附属医院胸心血管外科;复旦大学附属公共卫生临床中心 |
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| 基金项目： | 河南省卫生科技攻关项目(2006148) |
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| 摘 要： | 目的研究基质金属蛋白酶-9(MMP-9)和组织基质金属蛋白酶抑制剂-2(TIMP-2)在人非小细胞肺癌(NSCLC)组织中的表达及其与肺癌分期、分化程度和淋巴结转移等病理特征的相关性。方法通过免疫组织化学方法检测非小细胞肺癌组织和癌周组织中MMP-9和TIMP-2的蛋白表达,进行统计学处理。结果 MMP-9和TIMP-2在肺癌组织中的表达强于癌周肺组织,在腺癌中的表达强于鳞癌,在合并淋巴结转移的肺癌组织中表达较高。结论 MMP-9或TIMP-2表达失衡是NSCLC发生发展的关键。
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| 关 键 词： | 非小细胞肺癌 基质金属蛋白酶-9(MMP-9) 组织基质金属蛋白酶抑制剂-2(TIMP-2) 免疫组化 |
Expression of MMP-9 and TIMP-2 in Non-Small-Cell Lung Cancer and its Relationship with Clinical Pathological Features |
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| Institution: | ZHENG-Xianjie1,SUN-Mingfei1,ZHANG-Shuanglin1*,SONG-Yanzheng2,ZHANG-Xiaoyang1(1.Department of chest surgery the First Affiliated Hospital of Henan University,Kaifeng,Henan 475003,China;2.Public Heath Clinical Center Affiliated to Fudan University,ShangHai 200540,China) |
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| Abstract: | Objective To study the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-2 in Non-small cell lung cancer(NSCLC),and relation to clinical pathological features.Methods The expression of MMP-9 and TIMP-2 in NSCLC and paracancer pulmonary tissue were tested by immunohistochemical stain.Results MMP-9 and TIMP-2 express in all types of tissue,strongest in adenocarcinoma,lower in squamous carcinoma,lowest in para-cancer pulmonary tissue.There was significantly different between pulmonary tissue with and without lymph node transfer.Conclusion The imbalanced expression of MMP-9/TIMP-2 protein is the key enzyme of NSCLC invasion. |
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| Keywords: | lung cancer metalloproteinase-9(MMP-9) tissue inhibitors of metalloproteinase-2(TIMP-2) immunohistochemical stain |
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