Trabecular bone structure parameters from 3D image processing of clinical multi-slice and cone-beam computed tomography data |
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Authors: | Eva Klintström Örjan Smedby Rodrigo Moreno Torkel B Brismar |
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Institution: | 1. Center for Medical Image Science and Visualization (CMIV), Link?ping University, Link?ping, Sweden 3. Department of Radiology, UHL County Council of ?sterg?tland, Link?ping, Sweden 4. Department of Medical and Health Sciences (IMH)/Radiology, Link?ping University, 58185, Link?ping, Sweden 2. Department of Clinical Science, Intervention and Technology at Karolinska Institutet and Department of Radiology, KUS Huddinge, Stockholm, Sweden
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Abstract: | Objective Bone strength depends on both mineral content and bone structure. The aim of this in vitro study was to develop a method of quantitatively assessing trabecular bone structure by applying three-dimensional image processing to data acquired with multi-slice and cone-beam computed tomography using micro-computed tomography as a reference. Materials and Methods Fifteen bone samples from the radius were examined. After segmentation, quantitative measures of bone volume, trabecular thickness, trabecular separation, trabecular number, trabecular nodes, and trabecular termini were obtained. Results The clinical machines overestimated bone volume and trabecular thickness and underestimated trabecular nodes and number, but cone-beam CT to a lesser extent. Parameters obtained from cone beam CT were strongly correlated with μCT, with correlation coefficients between 0.93 and 0.98 for all parameters except trabecular termini. Conclusions The high correlation between cone-beam CT and micro-CT suggest the possibility of quantifying and monitoring changes of trabecular bone microarchitecture in vivo using cone beam CT. |
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