多囊卵巢综合征患者脂联素水平的变化及意义

目的研究多囊卵巢综合征(PCOS)患者血清脂联素水平的变化,探讨其参与PCOS发生发展的可能机制。方法①按照体质量指数(BMI)<24kg/m2,24kg/m2≤BMI<28kg/m2,BMI≥28kg/m2分别将初诊P-COS患者170例,分为正常体质量组(P1组69例)、超重组(P2组44例)、肥胖组(P3组57例);年龄和BMI相匹配的正常对照者143名分为正常体质量组(C1组102例)、超重组(C2组20例)、肥胖组(C3组21例)。②于月经第3～5天早8:00抽取空腹血,测定性激素、血脂、脂联素等指标;实施标准口服葡萄糖耐量试验(OGTT)、胰岛素激发试验;同时测量身高、体质量、腰围、臀围等。③基础与糖负荷后胰岛素分泌功能及胰岛素抵抗,按HOMA模型计算。结果①脂联素水平的变化:PCOS患者脂联素水平低于年龄和体质量指数相匹配的健康对照者(P1

Significance and changes of serum adiponectin levels in patients with polycystic ovarian sydrome

Objective To investigate the serum adiponectin level and its role in the polycystic ovary syndrome(PCOS).Methods ①One hundred and seventy women with PCOS(group P)and 143 controls(group C) who were age-and weight-matched were enrolled.Both were divided into three subgroups according to the BMI :group P1 and C1(BMI<24 kg/m2);group P2 and C2(24≤BMI<28 kg/m2);group P3 and C3(BMI≥28 kg/m2).②Blood samples were collected at 8:00 am,after an overnight fast in one of the third to fifth days of the menstrual cycle.Serum levels of sex hormones,lipids,glucose,insulin,adiponectin,luteinizing hormone(LH) and follicle-stimulating hormone(FSH) were estimated.Then all subjects underwent 75 g oral glucose tolerance test and insulin challenge test.At the same time,height,weight,waist circumference(WC) and hip circumference(HC) were also measured.③Indicators of insulin secretion and insulin resistance:homeostasis model assessment.Results ①The change of serum adiponectin levels:serum adiponectin levels were decreased with the increase of BMI both in the PCOS patients and controls(P1>P2>P3,C1>C2>C3,P<0.01);Serum adiponectin levels in the PCOS patients were lower than those in the control groups(P1