16层首过时间动态增强CT评价周围型非小细胞肺癌血管生成与病理学特征相关性的研究

目的探讨16层首过时间动态增强CT评价周围型非小细胞肺癌(NSCLC)血管生成及其病理学特征的价值。方法33例周围型NSCLC患者行首过时间动态CT检查,记录首过时间强化峰值(PH),采用CD34免疫组化(S-P法),测定微血管密度(MVD),评价首过时间PH值与MVD的相关性。结果33例患者首过时间PH值及MVD不同N分期(N0与N1-2组)间差异有统计学意义(P<0.01),首过时间PH值与MVD呈正相关(r=0.793,P=0.000)。首过时间PH值判断NSCLC有无淋巴结转移(N0与N1-2)的最佳界值点为12 HU,利用该界值点判断N分期的敏感度、特异度、准确率、阳性和阴性预测值分别为88.0%、75.0%、84.8%、91.7%和66.7%。结论肺部首过时间动态增强CT有在活体替代MVD评价周围性非小细胞肺癌病理学特征的能力,首过时间PH值可能成为常规CT对NSCLC分期的有效补充。

Non-small cell lung cancer evaluated by first pass dynamic contrast-enhanced 16-slice spiral CT: correlation of tumor vascularity with pathological characteristics

Objective To investigate the role of first pass dynamic 16-slice spiral computed tomography in the evaluation of tumor angiogenesis in patients with non-small cell lung cancer (NSCLC) and to assess its importance in predicting pathologic characteristics. Methods The first pass dynamic 16-slice spiral computed tomography was performed in 33 patients with NSCLC. Their peak heights (PH) were measured with dynamic evaluation software. Their angiogenesis were labelled by anti-CD34 monoclonal antibody. The first pass peak heights (PH) in 33 patients with NSCLC were compared with their microvessel densities (MVD) and their relationships were assessed by linear regression analysis. Results Among the 33 patients with NSCLCs, the mean first pass PH and MVD of N1-2 were significantly higher than those at stage N0(P<0.01). The first pass PH of 33 NSCLC was correlated positively with MVDs. To differentiate stage N0 from stage N1-2 with 12 HU cutoff value of the first pass PH, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 88. 0% , 75. 0% , 84. 8% , 91.7% and 66. 7% , respectively. Conclusion The first pass dynamic contrast enhanced CT may be a predictor of tumor angiogenesis in patients with NSCLC and its pathologic characteristics, and may be helpful to improve the accuracy of lymph node staging with conventional CT.