河南省3084例育龄男女弓形虫、风疹病毒、巨细胞病毒、单纯疱疹病毒感染状况调查分析

目的了解目前河南省育龄人群感染弓形虫（Tox）、风疹病毒（RV）、巨细胞病毒（CMV）、单纯疱疹病毒（HSV）Ⅰ／Ⅱ型的现状。方法采用酶联免疫吸附试验（ELISA）对2011年7—9月来郑州大学第一附属医院进行孕前咨询的3084例育龄男女进行上述病原（TORCH）感染的特异性IgM及IgG抗体检测。依据研究人群的性别及年龄进行分组，并对组间的TORCH特异性抗体阳性率采用X^2检验进行统计学分析。结果育龄人群TORCHIgM抗体总阳性率为5．5％（170／3084），其中RVIgM抗体阳性率最高（2．9％），其次为HSV（1．0％）；在IgG抗体方面，HSVIgG抗体阳性率最高（90．4％），其次为CMVIgG（89．7％）、RVIgG（48．1％）和Tox IgG（0．7％）。从年龄来看，〉30～40岁组各病原体的IgM抗体阳性率普遍较低；而IgG抗体方面，Tox、CMV及HSV IgG抗体阳性率随着年龄的增长呈现上升趋势，但RVIgG抗体阳性率却随着年龄的增长呈下降趋势。育龄女性人群的CMV和HSV IgG抗体阳性率显著高于男性（矿=83．470和7．026，P〈0．01）。结论河南省育龄人群中存在一定比例的TORCH现症感染及较低的RV IgG阳性率，建议育龄人群孕前进行TORCH筛查。

Prevalence of toxoplasma, rubella virus, cytomegalovirus and herpes simplex virus infections among 3084 individuals with childbearing-age in Henan province

Objective To investigate the prevalence of toxoplasma gondii （Tox）, rubella virus （ RV）, cytomegalovirus （CMV） and herpes simplex virus （HSV） infections （ TORCH infections） among childbearing-age population in Henan province. Methods Enzyme-linked immunosorbent assay （ELISA） was applied to detect plasma TORCH IgM and IgG among 3084 childbearing-age men and women from the First Affiliated Hospital of Zhengzhou University during July and September, 2011. The positive rates of anti-TORCH antibodies were compared among the various age and gender groups by X^2 test. Results The total positive rate of anti-TORCH IgM was 5.5% （ 170/3084）, in which the positive rate of anti-RV IgM was the highest （2.9%）, followed by anti-HSV IgM （ 1.0% ）. Within positive rate of anti-TORCH IgG, anti-HSV IgG was the highest （90.4%）, followed by anti-CMV IgG （89.7%）, RV IgG （48. 1% ） and Tox IgG （0.7%）. The positive rate of anti-TORCH IgM was the lowest in individuals aged 〉 30-40 year old. With the age increasing, the positive rates of anti-Tox IgG, anti-CMV IgG and anti-HSV IgG increased, but the positive rate of anti-RV IgG decreased. Women had higher positive rates of anti-CMV IgG and anti-HSV IgG than men （X^2 =83.470 and7.026, P〈0.01）. Conclusions Current infection of TORCH exists in childbearing-age population of Henan province, and the positive rate of anti-RV IgG is low. It is recommended to screen for TORCH infection in childbearing-age men and women.