Reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride and biological activities of the products |
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| Authors: | Modzelewska-Banachiewicz Bozena Ucherek Marzena Zimecki Michał Kutkowska Jolanta Kaminska Teresa Morak-Młodawska Beata Paprocka Renata Szulc Michał Lewandowski Grzegorz Marciniak Joanna Bobkiewicz-Kozlowska Teresa |
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| Affiliation: | Faculty of Pharmacy, Department of Organic Chemistry, Nicolaus Copernicus University, Bydgoszcz, Poland. |
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| Abstract: | A series of novel compounds were synthesized in reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H(1) NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti-inflammatory activities were experimentally verified. |
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| Keywords: | Analgesic activity Anti‐bacterial activity Anti‐inflammatory activity Synthesis |
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