质子敏感性OGR1亚家族及其研究进展

卵巢癌G蛋白偶联受体1（OGR1）亚家族是新近发现的一类对质子敏感的G蛋白偶联受体，它包括诱导细胞停滞于G2/M期的G蛋白偶联受体G2A（G2 accumulation）、T细胞死亡偶联基因8（ T-cell death-associated gene 8，TDAG8）、G蛋白偶联受体4（G protein-coupled receptor 4， GPR4）及OGR1，它们相互之间具有40%~50%的序列同源性。一些脂质分子目前被认为是该类受体的配体，并且该类受体还能通过组氨酸残基感知胞外质子或pH值的变化。该亚家族可通过几种异源三聚体G蛋白包括Gs，Gi，Gq及G12/13介导细胞内多种信号通路，与肿瘤的发生、细胞骨架重组、免疫系统和血管系统功能等生理病理过程有关。

Research advances on the proton sensing OGR1 subfamily

Recently,scientists have found a type of proton sensing G protein-coupled receptor (GPCR) subfamily including the G2 accumulation（G2A）， T-cell death-associated gene 8（TDAG8）, GPR4 and ovarian cancer G protein-coupled receptor 1 （OGR1）, which share 40%~50% sequence homology with each other.Some bioactive lysolipids have identified as the ligands of these receptors, and these receptors can sense extracellular protons or pH through histidine residues of receptors. These receptors can stimulate a variety of intracellular signaling pathways through several species of hetero-trimeric G-proteins, including Gs, Gi, Gq, and G12/13. They may play an important role in a variety of physiological and pathophysiological states.