| 血性脑脊液对内皮细胞分泌ET和NO的影响 |
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| 引用本文： | 邵国富,张志琳,楚冰,包仕尧,黄强. 血性脑脊液对内皮细胞分泌ET和NO的影响[J]. 中国临床神经科学, 2000, 8(2): 89-91 |
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| 作者姓名： | 邵国富 张志琳 楚冰 包仕尧 黄强 |
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| 作者单位： | 1. 苏州医学院附属二院神经内科,215004
2. 苏州医学院附属二院神经外科,215004 |
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| 摘 要： | 目的观察血性脑脊液对内皮细胞分泌内皮素(Endothelin,ET)和一氧化氮(NitricOxyde,NO)的影响。方法建立脐静脉内皮细胞体外培养的方法,用放射免疫方法测定ET含量,用硝酸还原酶法测定NO的代谢产物NO
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| 关 键 词： | 蛛网膜下腔出血 血性脑脊液 内皮素 一氧化氮 |
| 修稿时间： | 1999-04-15 |
Effect of BCSF on the Secretion of Endothelin and Nitric Oxide in Endothelial Cells |
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| SHAO Guo-Fu ,ZHANG Zhi-Lin ). Effect of BCSF on the Secretion of Endothelin and Nitric Oxide in Endothelial Cells[J]. Chinese Journal of Clinical Neurosciences, 2000, 8(2): 89-91 |
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| Authors: | SHAO Guo-Fu ZHANG Zhi-Lin ) |
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| Affiliation: | SHAO Guo-Fu ,ZHANG Zhi-Lin (Department of Neurology,the Second Hospital Affiliated to Suzhou Medical College(215OO4)) |
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| Abstract: | Aim: To study the effect of bloody cerebrospinal fluid (BCSF) on the secretion of endothelin (ET) and nitric oxide (NO) from human endothelial cells. Methods: The endothelial cells cultures from human umbilical vein were estab- lished. Concentration of ET and metabolic production of NO,NO_2~-/NO_3~-(NO_x~-) were determined by using radioimmunoassay and HNO3 reductase respectively, and effects of bloody cerebrospinal fluid (BCSF) were conducted. Results: BCSF of various stage could induce increase of ET and decrease of NO_x~- (P<0. 01) secreted by endothelial cells (P<0. 01). Conclusion: BSCF could induce increase of ET and decrease of NO_x~- secreted by endothelial cells cultured. |
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| Keywords: | subarachnoid hemorrhage bloody cerebrospinal fluid endothelin nitric oxide |
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