| 结肠肿瘤PTHrP的表达及其与P53蛋白表达关系的研究 |
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| 引用本文： | 郭敏,段芳龄,马军,白经修.结肠肿瘤PTHrP的表达及其与P53蛋白表达关系的研究[J].胃肠病学和肝病学杂志,2000,9(2):97-99. |
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| 作者姓名： | 郭敏 段芳龄 马军 白经修 |
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| 作者单位： | 河南医科大学消化疾病研究所,郑州市,450003 |
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| 摘 要： | 目的 研究ＰＴＨｒＰ在肿瘤发生过程中的作用以及ＰＴＨｒＰ和Ｐ５３在结肠腺中表达的关系。方法 用免疫组织化学ＡＢＣ法对６８例结肠组织（３０例结肠腺癌，２０例腺瘤性息肉，１８例正常结肠组织）进行ＰＴＨｒＰ检测，并对其中３０例结肠腺癌进行Ｐ５３检测。结果 结肠癌组ＰＴＨｒＰ的阳性率明显高于腺瘤组（Ｐ〈０．０５）和正常组（Ｐ〈０．０５）。绫 ＰＴＨｒＰ的过度表达与细胞的恶性 经有关，与肿瘤分化程度无明显关
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| 关 键 词： | 结肠肿瘤 PTHrP P53 免疫组织化学 |
| 修稿时间： | 2000年3月24日 |
Study on expression of PTHrP and its relationship with p53 in colon carcinoma |
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| Guo Min,Duan Fangling,Ma Jun,et al..Study on expression of PTHrP and its relationship with p53 in colon carcinoma[J].Chinese Journal of Gastroenterology and Hepatology,2000,9(2):97-99. |
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| Authors: | Guo Min Duan Fangling Ma Jun |
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| Institution: | Guo Min,Duan Fangling,Ma Jun,et al. Digestive Disesae Institute,Henan Medical University,Zhengzhou,450003 |
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| Abstract: | Aim To investigate the role of PTHrp in carcinogenesis and the relationship between PTHrP and P53 expression. Method Using immunohistochemical stain(ABC), we detected PTHrP in 68 samples of colon (including 30 colon carcinoma, 20 adenomatous polyps and 18 normal colon tissus). P53 was also detected in 30 samples of colon carcinoma. Results Positive rate of PTHrP expression in colon carcinoma was significantly higher than that of adenomatous polyps ( P <0 05) and normal colon tissue ( P <0 01). There was no difference between highly and poorly differentiated carcinoma( P >0.05).Expression of PTHrP and P53 had correlation in colon carcinoma ( P <0 05).Conclusion The expression of PTHrP is associated with the malignant transformation of normal cells, yet not associated with the degree of cell differentiation. PTHrP and P53 may contribute to the pathogenesis of tumor. |
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| Keywords: | Colon carcinoma PTHrP P53 Immunohistochemistry |
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