| 黄连素对糖尿病大鼠脑组织的保护作用 |
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| 引用本文： | 赵晓莲,隋洪玉,李凯霞,关政,马奎利,栾海燕. 黄连素对糖尿病大鼠脑组织的保护作用[J]. 黑龙江医药科学, 2006, 29(3): 4-5 |
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| 作者姓名： | 赵晓莲 隋洪玉 李凯霞 关政 马奎利 栾海燕 |
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| 作者单位： | 佳木斯大学基础医学院生理教研室,黑龙江,佳木斯,154007;佳木斯大学基础医学院生理教研室,黑龙江,佳木斯,154007;佳木斯大学基础医学院生理教研室,黑龙江,佳木斯,154007;佳木斯大学基础医学院生理教研室,黑龙江,佳木斯,154007;佳木斯大学基础医学院生理教研室,黑龙江,佳木斯,154007;佳木斯大学基础医学院生理教研室,黑龙江,佳木斯,154007 |
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| 摘 要： | 目的：观察黄连素对Ⅱ型糖尿病大鼠脑组织的保护作用。方法：用链尿佐菌素复制糖尿病大鼠模型，观察黄连素对糖尿病大鼠脑组织细胞色素C、线粒体Ca^2＋的影响。结果：模型组脑组织线粒体细胞色素C显著低于正常组和黄连素组（P〈0.05），胞浆细胞色素C、线粒体Ca^2＋均显著高于正常组和黄连素组，差异有统计学意义（P〈0．05）。结论：细胞色素C、钙离子参与脑细胞损伤。黄连素对糖尿病大鼠脑组织具有保护作用。
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| 关 键 词： | 黄连素 Ⅱ型糖尿病 脑组织 细胞色素C 线粒体Ca2+ |
| 文章编号： | 1008-0104(2006)03-0004-01 |
| 修稿时间： | 2006-03-12 |
Protection of Berberine in NIDDM rat brain |
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| ZHAO Xiao-lian,SUI Hong-yu,LI Kai-xia,GUAN Zheng,MA Kui-li,LUAN Hai-yan. Protection of Berberine in NIDDM rat brain[J]. Heilongjiang Medicine and Pharmacy, 2006, 29(3): 4-5 |
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| Authors: | ZHAO Xiao-lian SUI Hong-yu LI Kai-xia GUAN Zheng MA Kui-li LUAN Hai-yan |
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| Abstract: | Objective: To observe the protection of Berberine in the brain of NIDDM rats.Methods: We randomly divided 40 male Wistar rats into three groups(normal group,model group and Berberine group).We duplicated NIDDM rat model with streptozocin and observed the effects of Berberine on cytochrome C and mitochondrial calcium of the NIDDM rat brain.Results: The rat NIDDM model was successfully prepared,and in model group,the mitochondrial Cyt-C level in the rat brain was lowered((P<0.05)),while Plasma Cyt-C and mitochondrial calcium were higher(P<0.05),compared with the normal and Berberine group.Conclusion: Cyt-C and calcium ion participate in brain damage,and Berberine can protect NIDDM rat brain. |
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| Keywords: | Berberine NIDDM cytochrome C mitochondrial calcium |
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