天麦消渴片治疗肥胖伴胰岛素抵抗型多囊卵巢综合征疗效观察

目的：观察新型胰岛素增敏剂天麦消渴片对肥胖伴胰岛素抵抗（IR）型多囊卵巢综合征（PCOS）患者排卵、糖、脂代谢及生殖激素方面的影响。方法：在饮食运动控制基础上应用天麦消渴片治疗肥胖伴胰岛素抵抗型多囊卵巢综合征患者70例，持续12周，采用自身对照法观察患者治疗前、后体重指数（BMI）、腰臀比（WHR）、空腹血糖（FPG）、餐后2h血糖（2hPG）、相同时间点空腹胰岛素（FINS）、餐后2h胰岛素（PINS）、胰岛素抵抗指数（HOMA—IR）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三脂（TG）、低密度脂蛋白（LDL—C）、高密度脂蛋白（HDL—C）、黄体生成激素（LH）、卵泡刺激素（FSH）和睾酮（T）、LH／FSH水平的变化。结果：70例患者中57例（81．4％）月经和排卵功能改善，其中2例（2．85％）妊娠。BMI较治疗前相比有所下降，但差异无统计学意义（P〉O．05），WHR较治疗前下降，差异有统计学意义（P〈0．05）；FPG、2hPG、FINS、PINS、HbA1c、HOMA—IR较治疗前显著下降（P〈0．05）；治疗后TC、TG、LDL—C较治疗前显著下降（P〈0．05），HDL—C较治疗前显著升高（P〈0．05）；治疗后LH、T和LHWSH均显著下降（P〈0．05），但FSH无明显变化（P〉0．05）。结论：天麦消渴片可通过增加胰岛素敏感性改善胰岛素抵抗，从而改善肥胖伴胰岛素抵抗型多囊卵巢综合征患者异常的糖代谢、脂肪代谢、调节生殖激素水平，恢复排卵功能。

The Effect of Tianmaixiaoke Tablet on Obesity with Insulin Resistance in Women with Polycystic Ovary Syndrome

Objective： To observe the effects of the new insulin sensitizer Tianmaixiaoke tablet on obesity with insulin resistance （ IR ） type of polycystic ovary syndrome （PCOS）patients, the effects include ovulation, glucose, lipid metabolism and reproductive hormones aspects.Method： In the diet and motion control basis, used the Tianmaixiaoke tablets in the treatment of obesity with insulin resistance in patients with polycystic ovarian syndrome 70 cases lasted 12 weeks, observed before and after the treatment change by using self-controlled study, Including： clinical symptoms, fasting plasma glucose （ FPG ） . 2 h postprandial plasma glucose （ 2 h PG ）, and the same time of fasting serum insulin （ FINS ）, 2 h postprandial insulin （ PINS ）, insulin resistance index （ HOMA-IR ）, glycosylated hemoglobin （ HbA1c ）, total cholesterol （ TC ）, glycerin three greases （ TG ）, low density lipoprotein （ LDL-C ）, high density lipoprotein （ HDL-C ）, body mass index （ BMI ）, waist hip ratio （ WHR ）, luteinizing hormone （ LH ）, follicle stimulating hormone （ FSH ） and testosterone （ T ） .Result： Menstruation and ovulation function recovered in 57 of 70 （ 81.4% ）, of which 2 cases （ 2.85% ）pregnancy, BMI were declined, but there was no significant difference （ P〉0.05 ） WHR were significantly decreased after 12 weeks （ P〈0.05 ） ; FPG, 2 h PG.FINS, PINS, HbA1c and HOMA-IR were significantlydecreased （ P〈0.05 ） ;TC, TG, LDL-C were significantly decreased （ P〈0.05 ）, HDL-C was significantly increased （P〈0.05 ） ;Alter treatment with T, LH, LH/FSH ratio （ LH/FSH ） were significantly decreased （P〈0.05）, but FSH levels showed no significant change （ P〉0.05 ） .Conclusion： Tianmaixiaoke tablet mainly through increasing insulin sensitivity to reduce insulin resistance, thereby improving abnormal glucose and lipid metabolism, regulating reproductive hormone to recovery ovulation function of obesity with insulin resistance in patients with polycystic ovary syndrome.