达因-35及二甲双胍预处理对肥胖型多囊卵巢综合征促排卵治疗的影响

目的探讨达因-35及二甲双胍预处理对肥胖型多囊卵巢综合征患者促排卵的临床效果。方法 40例多囊卵巢综合征患者随机分为2组,观察组22例给予达因-35联合二甲双胍治疗,对照组18例只给予达因☆5治疗,疗程均3个月,2组给予氯米芬及HCG促排卵,观察治疗前后内分泌相关指标、排卵及妊娠等情况。结果观察组治疗后体质量指数均明显降低(P<0.05)。观察组除空腹血糖外,空腹胰岛素、血糖及胰岛素曲线下面积(AUC)、胰岛素抵抗指数(HOMA-IR)水平治疗后均明显下降(P<0.05),与对照组比较差异有统计学意义(p<0.05);2组患者治疗后LH、T及LH/FSH比值均有明显改善,但观察组改善较对照组更明显(P<0.05);观察组排卵率为68.2%,妊娠率为40.9%,优于对照组的排卵率50.0%、妊娠率27.8%(P<0.05)。结论达因-35联合二甲双胍对降低肥胖型多囊卵巢综合征雄激素水平,改善胰岛素抵抗,提高排卯及妊娠率有明显效果。

The therapeutic effect of the Dyne-35 and pretreatment of metformin on obese polycystic ovary syndrome promoting ovulation

Objective To study the effect on obese polycystic ovary syndrome with metformin Dyne-35 and observe clinical effect on ovulation.Methods 40 cases of polycystic ovarian syndrome were enrolled and divided into two groups,experimental group(n = 22) were given Dyne 35 and metformin treated for 3 months,control group(n =18) only treated with metformin for 3 months.Clomiphene and HCG were given then in both groups,effect on endocrine related indicators,before and after ovulation and pregnancy were observed.Results BMI were decreased in experimental group(P <0.05).Except fasting blood glucose,all other indexes included fasting insulin,AUC(blood glucose),and AUC(insulin),and HOMA-IR level were decreased obviously(P <0.05),and there were significant differences between the two group(P <0.05).LH, T and LH/FSH ratio were improved in both groups,but experimental group were better than control group(P <0.05).Experimental group ovulation rate was 68.2%,pregnancy rate was 40.9%,which were better than control group of ovulation rate 50.0%,pregnancy rate 27.8%(P <0.05).Conclusion Dyne-35 combined with metformin can reduce androgen levels in obese polycystic ovary syndrome,improve insulin resistance,ovulation and pregnancy rates.