| LOX-1在ox-LDL诱导血管平滑肌细胞表达Fractalkine中的作用及罗布麻的干预 |
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| 引用本文： | 李建微,郑杨,金元哲.LOX-1在ox-LDL诱导血管平滑肌细胞表达Fractalkine中的作用及罗布麻的干预[J].临床心血管病杂志,2009,25(4). |
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| 作者姓名： | 李建微 郑杨 金元哲 |
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| 作者单位： | 1. 中国医科大学附属第四医院心内科,沈阳,110032
2. 吉林大学第一临床医院心内科 |
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| 摘 要： | 目的:研究血凝素样氧化低密度脂蛋白受体-1(LOX-1)在氧化型低密度脂蛋白(ox-LDL)诱导血管平滑肌细胞(VSMC)表达不规则趋化因子(FKN)中的角色及罗布麻的干预作用.方法:用组织贴块培养法培养大鼠VSMC,应用ELISA法检测LOX-1蛋白表达、RT-PCR法检测FKN mRNA的表达.结果:ox-LDL可诱导大鼠VSMS高表达FKN,分别应用LOX-1的阻断剂角叉菜胶和罗布麻后,FKN的表达均明显下降(P<0.05).结论:在VSMC的炎症反应中,ox-LDL通过LOX-1途径激活了FKN的表达,高浓度罗布麻(0.8 g/L)可抑制FKN的表达,推测罗布麻可能起到抗炎、抗动脉粥样硬化的作用.
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| 关 键 词： | 氧化型低密度脂蛋白 血凝素样氧化低密度脂蛋白受体-1 动脉粥样硬化 趋化因子 罗布麻 |
Effects of LOX-1 on ox-LDL inducing Fractalkine signaling in vascular smooth muscle cell and the protective effect of Apocynum venetum |
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| LI Jianwei,ZHENG Yang,JIN Yuanzhe.Effects of LOX-1 on ox-LDL inducing Fractalkine signaling in vascular smooth muscle cell and the protective effect of Apocynum venetum[J].Journal of Clinical Cardiology,2009,25(4). |
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| Authors: | LI Jianwei ZHENG Yang JIN Yuanzhe |
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| Institution: | 1Department of Cardiology;Fouth Affiliated Hospital of China Medical University;Shenyang;110032;China;2Department of Cardiology;First Hospital Jilin University |
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| Abstract: | Objective:To investigate the role of LOX-1 in the process of ox-LDL inducing the expression of FKN in Vascular smooth muscle cell(VSMC) and the protective effects of Apocynum venetum.Method:VSMC were incubated in vitro and the expression of LOX-1,FKN mRNA were detected by ELISA and RT-PCR.Result:ox-LDL can induce the high expression of FKN in VSMC,while carrageenan,the inhibitor of LOX-1 and Apocynum venetum can inhibit the expression of FKN obviously(P<0.05).Conclusion:In the inflammation of VSMC,the expre... |
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| Keywords: | Fractalkine |
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