Nitric oxide synthase expressions in rat dorsal root ganglion after a hind limb tourniquet |
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Authors: | Abe Sumiko Mizusawa Ikubumi Kanno Katsuyuki Yabashi Atsuko Suto Miwako Kuraya Mikio Honda Takashi Hiraiwa Kouichi |
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Institution: | Department of Legal Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan. sumiko@fmu.ac.jp |
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Abstract: | We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Significantly high nNOS, iNOS mRNA and protein levels were observed in the ipsilateral DRGs 4 h after tourniquet application but not in the contralateral or control DRGs. The levels of TNF-alpha, an inducer of iNOS, were significantly increased in the ipsilateral DRGs 1 h after tourniquet application. Large amounts of NO might result in damage to the host cells and induce apotosis to eliminate damaged cells during the early stage of nerve injury. |
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