| 地特胰岛素在2型糖尿病中的应用 |
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| 引用本文： | 于佩,孟振兴,周赛君,于德民.地特胰岛素在2型糖尿病中的应用[J].临床药物治疗杂志,2013,0(1):19-23. |
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| 作者姓名： | 于佩 孟振兴 周赛君 于德民 |
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| 作者单位： | 天津医科大学代谢病医院糖尿病肾病血液透析科卫生部激素与发育重点实验室 天津 300070 |
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| 摘 要： | 地特胰岛素是一种新型的基础胰岛素类似物,其入血后可形成独特的双六聚体-白蛋白复合物,发挥长效降糖作用。地特胰岛素疗效可靠,并具有低血糖发生率低、个体内变异性小、体重增加少等临床特点,而体重增加少更是其独特的优势。多项临床研究表明,"基础+口服药"治疗(BOT)方案中每天1次使用地特胰岛素能够达到有效控制血糖的目标。采用303算法或者医生指导调节胰岛素用量可获得同样的效果。
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| 关 键 词： | 地特胰岛素 2型糖尿病 临床疗效 临床应用 不良反应 |
Application of Insulin Detemir in Patients with Type 2 Diabetes Mellitus |
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| Yu Pei,Meng Zhen-xing,Zhou Sai-jun,Yu De-min.Application of Insulin Detemir in Patients with Type 2 Diabetes Mellitus[J].Clinical Medication JOurnal,2013,0(1):19-23. |
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| Authors: | Yu Pei Meng Zhen-xing Zhou Sai-jun Yu De-min |
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| Institution: | .Key Lab of Hormones and Development,Ministry of Health,Department of hemodialysis of Diabetic Nephrology,The Metabolic Disease Hospital of Tianjin Medical University,Tianjin 300070,China |
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| Abstract: | Insulin detemir is a new basal insulin analogue,which could form the dual hexamer-albumin complex in the blood to have a prolonged hypoglycemic effect.Its clinical efficacy is quite satisfactory,with low incidence of hypoglycemia,low within-subject variability in blood glucose concentration,less weight gain and other clinical features,and less weight gain is the unique advantage.A number of trials have shown that BOT（＂basal ＋ oral＂ therapy） with once-daily detemir achieved effective control of blood glucose.To adjust the dose of insulin,there is no significant difference between 303 algorithm and doctor＇s guidance. |
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| Keywords: | insulin detemir type 2 diabetes mel itus efficacy application adverse reactions |
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