刺五加与甲氯芬酯对失眠症患者睡眠质量的影响

目的 探讨刺五加与甲氯芬酯对失眠症的疗效及睡眠质量指数的变化.方法 将失眠症患者80例随机分成两组,治疗组在常规治疗基础上给予刺五加针80ml加生理盐水及盐酸甲氯芬酯0.4g再加5%葡萄糖注射液250ml静脉静滴,Qd×14d;对照组给予安定片2.5～7.5mg,睡前30min口服,14d为1个疗程.两组均给予支持性心理治疗和环境调整.观察治疗前后患者主观睡眠维持时间、入睡潜伏时限、醒后的精神状态和工作效率的变化及匹兹堡睡眠质量指数改变.结果 根据患者主观睡眠维持时间、入睡潜伏时、醒后的精神状态和工作效率的变化,治疗组有效率达90%,对照组有效率为55%,治疗组明显高于对照组,差异有统计学意义(P＜0.01).两组的匹兹堡睡眠质量指数和评分比较显示,治疗组治疗后总分为(4.22±3.26)分,低于对照组(9.34±3.58)分,二者比较差异有统计学意义(t=2.18,P＜0.05),在其他分值上治疗组疗效均优于对照组(t=2.08～3.21,P＜0.05).结论 刺五加与甲氯芬酯联合治疗失眠症不仅可以改善患者对睡眠的主观评价,而且还可以减少白天困倦,改善日间脑功能,调整睡眠觉醒周期,提高患者生活质量.

Effect of Ciwujia injection and medofenoxate on sleep quality of insomaiacs

Objective To evaluate the effect and sleep quality index of Ciwujia injection and medofenoxate on insomnia patients.Methods Eighty insomniacs were randomly divided into the treatment group and the control group,and were respectively given Ciwujia injection and medofenoxate,diazepam.One course of treatment was 14d.Results After treatment,total effective rate in the treatment and the control group was 90% and 55% respectively.In comparison with control group,total effective rate of the treatment group was notably higher(P<0.01).The Pittsburgh sleep quality index(PSQI) score of the treatment group was lower than that of the control group(P<0.05).Conclusion Ciwujia injection and medofenoxate applied to treat insomnia is a good way to improve subjective sleep quality,reduce the drowsiness in day,adjust the sleep rhythm and enrich our life quality.