黄体期避孕对月经影响的临床研究

目的:评估当妇女在月经周期有无保护性生活超过120h,或多次无保护性生活后于黄体期避孕对月经的影响。方法:在黄体期1次性服用米非司酮100mg并在36~48h后服用米索前列醇400μg,服药后观察月经情况。结果:100例受试者中4例妊娠,在成功避孕的96例中,月经提前68例(70·83%),延期15例(15·6%),无改变13例(13·5%)。服药前后比较,月经周期缩短,差异有显著性意义(P<0.01),服药后月经出血天数5·76±1·18天,与妇女原来出血天数比较差异有显著性意义(P<0.05),与服药前自身经量比较,经量减少1例,相似90例,增多5例,经量与服药前差异无显著性意义(P>0.05)。服药距下次月经时间为6·85±1·88天,服药距下次月经9~7天组和6~4天组月经周期缩短,与服药前相比差异均有显著性意义(P<0.05),而3~1天组月经周期改变不明显(P>0.05);出血天数及经量3组间无显著性差异(P>0.05)。结论:黄体期避孕有效率为96%,该方法可使妇女月经周期缩短,经期延长,且服药距下次月经时间长对月经周期影响较大。

Clinical Study of the Influence of Contraception in Lteal Phase on Menstruation

Objective: To observe the influence of contraception in luteal phase on menstruation. Methods: The sequential mifepristone-misoprostol regimen used 100mg oral dose of mifepristone followed 36-48hours later by 0.4mg oral dose misopristol. The menstrual status was observed after treatment. Results: The present results showed that menstrual cycle was 27.56days and 28.87days after and before treatment, respectively. It showed significant difference in menstrual cycle between two groups(P<0.01) .The menstrual bleeding day was 5.76 days and 5.42 days after and before treatment respectively. The menstrual bleeding day was increased significantly after treatment(P<0.05). Conclusions: The sequential regiment can decrease menstrual cycle and increase menstrual bleeding day during the luteal phase to the contraception and the initial time of treatment with sequential regimen in luteal phase can influence menstrual cycle.