| 选择性垂体甲状腺激素抵抗的新认识 |
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| 引用本文： | 陈吉海,王坚.选择性垂体甲状腺激素抵抗的新认识[J].国际内分泌代谢杂志,2009,29(4). |
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| 作者姓名： | 陈吉海 王坚 |
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| 作者单位： | 南京军区南京总医院内分泌科,南方医科大学南京临床医学院,210002 |
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| 摘 要： | 选择性垂体甲状腺激素抵抗是甲状腺抵抗综合征中的一种少见类型,为一种常染色体显性遗传性疾病.主要由于甲状腺激素受体β亚基基因突变所致.它的临床特征为轻度甲状腺功能亢进,实验室检查提爪游离T3游离T4升高的同时伴有促甲状腺激素的不适当分泌.治疗可选用三碘甲状腺醋酸、右旋T4、溴隐亭等,目前尚无根治方法.
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| 关 键 词： | 垂体甲状腺激素抵抗 基因突变 β亚单位 三碘甲状腺醋酸 |
Pituitary resistance to thyroid hormone |
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| CHEN Ji-hai,WANG Jian.Pituitary resistance to thyroid hormone[J].International JOurnal of Endocrinology and Metabolism,2009,29(4). |
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| Authors: | CHEN Ji-hai WANG Jian |
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| Abstract: | Pituitary resistance to thyroid hormone(PRTH) is a kind of autosomal dominant hereditary disease. It is mainly caused by the mutations of the thyroid hormone receptor beta gene. The feature of labora-tory is elevated serum free thyroxine (FT4) and free triiodothyronine (TT3) with inappropriate TSH. 3,5,3'-triiodothyroacetic acid (TRIAC), D-T4, bromocriptine have been used in the therapy of PRTH, however, no radical cure has been found now. |
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| Keywords: | Pituitary resistance to thyroid hormone Gene mutation Beta subunit 3 5 3'-triiodothy-roacetic acid |
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