乌司他丁辅助治疗严重多发伤患者的疗效观察

[摘要]　目的 探讨乌司他丁在治疗严重的多发伤患者中的作用。方法 将92例严重多发伤患者随机分为治疗组46例，对照组46例。治疗组在常规处理的基础上加用乌司他丁20万单位静脉点滴，每日2次，连续用药7天。观察患者的死亡率和MODS的发生率，并在入院时及入院后第1、3、7天检测谷丙转氨酶(ALT)、谷草转氨酶(AST)、血肌酐(Scr)、肌酸激酶同工酶(CK-MB)及血浆肿瘤坏死因子-α(TNF-α)的浓度变化。 结果 治疗组ALT、AST、Scr、CK-MB及TNF-α的水平均较对照组低（P<0.05），治疗组MODS的发生率较对照组低（P<0.05）。 结论　乌司他丁能够保护严重多发伤患者的脏器功能，降低MODS的发生率。[关键词]　乌司他丁；多发伤；多器官功能障碍综合征

The effect of ulinastatin for the treatment severe multiple trauma

[Abstract] Objective To investigate the influence of Ulinastati on Severe Multiple Trauma. Methods 92 patients with serious trauma were randomly divided into two groups,46 for treatment group,46 for control group.The control group was trented with conventional therapy, the treatment group was treated with conventional therapy combined Ulinastati 200000 units,intravenous transfusion, twice daily for 7 days. ALT,AST,Scr,CK-MB and TNF-α were detected in the patients of two groups on admission, one, three and seven days after treatment respectively.The morbidity and mortality of multiple organ dysfunction syndrome (MODS) between the tow groups were statistically analyzed. Results The level of ALT,AST,Scr,CK-MB and TNF-α in treatment group were lower than control group（P<0.05）. The morbidity rate of MODS in treatment group was lower than control group（P<0.05）. Conclusions Ulinastati has a protective effect on organ function in Severe Multiple Trauma patients, and can decrease morbidity rate of MODS.[Key words] Ulinastati; Multiple trauma; Multiple Organ Dysfunction Syndrome