T cell anergy is programmed early after exposure to bacterial superantigen in vivo |
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| Authors: | Yuh Kouichi; Siminovitch Katherine A; Ochi Atsuo |
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| Institution: | 1 Departments of Immunology and Medical Genetics 600 University Ave, Toronto, Ontario, Canada M5G 1X5
2 Departments of Immunology, Medical Genetics and Medicine, University of Toronto, and Samuel Lunenfeld Research Institute of Mount Sinai Hospital 600 University Ave, Toronto, Ontario, Canada M5G 1X5 |
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| Abstract: | We have investigated the effects of the protein synthesis inhibitor,cycloheximide (CHX), on the induction of post-thymic T celltolerance in mice primed with the bacterial superantigen, Staphylococcusaureus enterotoxin B (SEB). A single injection of 1 mg CHX preventedprotein synthesis in splenic cells for <6 h in vivo. Theconcomitant administration of SEB and CHX prevented inductionof SEB-specific anergy, but did not interfere with the deletionof SEB-speclfic Vß8+ T cells by activation-induced,programmed cell death. When CHX was given  24 h after SEB administrationthe expression of anergy was not affected. These findings suggestthat anergy and deletion represent independent processes. Furthermore,these observations, together with the fact that SEB retainsthe potential to induce anergy in specific T cells 8 h afterpriming in vivo, imply that the determination of alternate fates(anergy or death) occurs at early time points after SEB injection |
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| Keywords: | peripheral tolerance programmed cell death staphylococcal enterotoxin B T cell anergy |
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