| 用于抗肿瘤的ATP竞争性纺锤体驱动蛋白抑制药的研究进展 |
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| 引用本文： | 汤东澄,黄学荪,刘金来,潘丽琴,江程.用于抗肿瘤的ATP竞争性纺锤体驱动蛋白抑制药的研究进展[J].中国药师,2015(3):420-426. |
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| 作者姓名： | 汤东澄 黄学荪 刘金来 潘丽琴 江程 |
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| 作者单位： | 永嘉县中医医院 浙江永嘉 325102；;温州医科大学附属第一医院；;温州市人民医院；;温州市人民医院；;中国药科大学药学院 |
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| 基金项目： | 国家自然科学基金青年基金(编号：30772624)；江苏省自然科学基金(编号：BK20110623)和江苏省“青蓝工程”项目 |
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| 摘 要： | 纺锤体驱动蛋白(kinesin spindle protein,KSP)抑制药是抗肿瘤药物研究的一个重要方向,已有数个KSP抑制药进入临床研究。ATP竞争性KSP抑制药的发现,为克服因为结合位点突变而引起的对ATP非竞争性KSP抑制药耐药提供了新的研究思路。本文综述了近年来报道的ATP竞争性KSP抑制药,为进一步的研究提供了参考。
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| 关 键 词： | 纺锤体驱动蛋白抑制药 ATP竞争性 抗肿瘤 |
| 收稿时间： | 2014/11/26 0:00:00 |
| 修稿时间： | 2014/12/27 0:00:00 |
Progress in ATP competitive Kinesin Spindle Protein Inhibitors as Anticancer Agents |
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| Tang Dongcheng,Huang Xuesun,Pan Liqin,Pan Liqin and Jiang Cheng.Progress in ATP competitive Kinesin Spindle Protein Inhibitors as Anticancer Agents[J].China Pharmacist,2015(3):420-426. |
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| Authors: | Tang Dongcheng Huang Xuesun Pan Liqin Pan Liqin and Jiang Cheng |
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| Institution: | Tang Dongcheng;Huang Xuesun;Liu Jinlai;Pan Liqin;Jiang Cheng;Yongjia County Hospital of Traditional Chinese Medicine;The First Affiliated Hospital of Wenzhou Medical University;Wenzhou Hospital;School of Pharmacy,China Pharmaceutical University; |
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| Abstract: | ABSTRACT Kinesin spindle protein (KSP) inhibitors is an important direction for the discovery of anticancer agents. Several KSP inhibitors have been studied in clinic trials. The discovery of ATP competitive KSP inhibitors may be a new approach for searching novel agents to overcome the mutation mediated resistance to the allosteric inhibitors. The progress in the discovery of ATP competitive KSP inhibitors was reviewed in the paper to provide reference for the further development of KSP inhibitors. |
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| Keywords: | Kinesin spindle protein inhibitors ATP competitive Anti cancer |
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