地塞米松对脑出血术后血清IL-6的影响

目的观察脑出血患者术后血清IL-6浓度的动态变化及地塞米松治疗对其表达的影响。方法随机将120例脑出血术后患者分为常规治疗组（n=60）、地塞米松治疗组（n=60），以60例健康体检者为对照组。测定术后第1、3、7、10、14天清晨空腹外周静脉血清IL-6、白细胞总数、单核细胞、淋巴细胞和CSS评分变化。结果常规治疗组术后第1天血清IL-6含量最高，第3天开始下降，第10天仍高于对照组（P〈0．05），第14天与对照组基本一致。地塞米松治疗组各期均低于常规治疗组（P〈0．05）。IL-6含量与单核细胞密切相关。结论血清IL-6参与了脑出血急性期的炎性病理生理过程，地塞米松可使血中IL-6含量降低，减轻炎性反应。

Effect of dexamethasone on the concentration of IL-6 of the cerebral hemorrhage patients after surgery

Objective To observe the serum dynamic change of IL-6 of the cerebral hemorrhage patients after surgery and the influence on them after dexamethasone treatment.Methods 120 cases with intracerebral hemorrhage after surgery were divided into two groups:routine reatment group(n=60)and dexamethasonet reatment group(n=60).60 healthy cases were adopted as control group.The content of IL-6,leukocyte,monoplast,lymphoidocyte were measurged in blood and CSS score were observed on the first day,third day,seventh day,tenth day,fourteenth day.Results The serum concentration of IL-6 raised and was highest on the first day after surgery,and began to drop on the third day,on the tenth day it was still higher in routine reatment group than the control group(P<0.05),it had no difference with the control group on the fourteenth day.That of the dexamethasone treatment group was lower than routine reatment group(P<0.05).The concentration of IL-6 were closely associated with monop last.Conclusion IL-6 is associated with the early inflammatory course of patients with acute intracerebral hemorrhage.Dexamethasone can reducethe serum concentration of IL-6,inhibit the inflammatory response.