DSP-4, a noradrenergic neurotoxin, produces more severe biochemical and functional deficits in aged than young rats |
| |
Authors: | Paavo Riekkinen Jr Minna Riekkinen Antti Valjakka Paavo Riekkinen Jouni Sirvio
|
| |
Institution: | aDepartment of Neurology, University of Kuopio, Kuopio Finland bDepartment of Pathology, University of Kuopio, Kuopio Finland |
| |
Abstract: | The present study examines the effects of noradrenergic lesions (either DSP-4 i.p. or 6-hydroxydopamine (6-OHDA) into the dorsal noradrenergic bundle on biochemical (noradrenaline (NA), dopamine (DA), serotonin (5-HT) and choline acetyltransferase (ChAT) activity) and cortical EEG (quantitative EEG (qEEG) and high-voltage spindle (HVS) activity in young and aged rats. Near complete 6-OHDA NA lesions, but not partial DSP-4 NA lesions, increased HVS activity in young rats. DSP-4 and 6-OHDA lesions produced no significant changes in the 5-HT or DA levels or in the ChAT activity in young rats. In some of the aged rats, DSP-4 produced similar biochemical and HVS effects, as it induced in young rats. In the remainder of the aged rats, NA levels were greatly and 5-HT levels slightly decreased. DA levels and ChAT activity were unaltered in either set of aged rats. HVS activity was increased only in that group of aged rats with the greatly lowered NA content. These results suggest that: (1) some of the aged rats are more sensitive to DSP-4 treatment than young adult rats; and (2) NA depletions have to be complete to produce an increase in HVS activity in young and aged rats. |
| |
Keywords: | Lesion Noradrenaline Dopamine Serotonin Choline acetyltransferase High-voltage spindle Young vs aged rat |
本文献已被 ScienceDirect 等数据库收录! |
|