Glutamate dehydrogenase in aminoacidergic structures of the postnatally developing rat cerebellum |
| |
| Authors: | G Wolf G Schünzel |
| |
| Affiliation: | 1. Lab de Neurofarmacologia, Instituto Biomédico (IB), Universidade Federal Fluminense, Brazil;2. Lab de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil;3. Lab Neuroanatomia Celular, Instituto de Ciências Biomédicas e Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil;4. Lab Neurobiologia da Retina, Dept Neurobiologia, Instituto de Biologia, Universidade Federal Fluminense, Brazil;1. Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria;2. Austrian Cluster for Tissue Regeneration, Vienna, Austria;3. Department of Neurosurgery, Medical University of Vienna, Vienna, Austria;4. Institute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria;5. University of Fribourg, Section of Science and Medicine, Department of Oncology, Microbiology and Immunology, Section of Pharmacology, Fribourg, Switzerland;6. Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA;7. A. N. Belozersky Institute of Physicochemical Biology, Lomonosov Moscow State University, 119234, Moscow, Russia;8. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia;9. Department of Biochemistry, Sechenov University, Moscow, Russia;10. Biological Faculty, Department of Biophysics, Lomonosov Moscow State University, Moscow, Russia;11. Institute of General Pathology and Pathophysiology, Laboratory of Fundamental and Applied Problems of Pain, Moscow, Russia;12. National Medical Research Center of Children''s Health, Russian Ministry of Health, Laboratory of Neurobiology and Brain Development, Moscow, Russia;13. Department of Biochemistry, Semmelweis University, Budapest, Hungary;14. Departments of Environmental and Occupational Health, Pharmacology and Chemical Biology, Chemistry and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA;15. Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children''s Neuroscience Institute, Children''s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA |
| |
| Abstract: | In the cerebellar cortex of the rat, histochemically demonstrable activity of glutamate dehydrogenase (GDH) was found to increase markedly after the second week of postnatal life. As evaluated histophotometrically, the amount of reaction product in Purkinje cell perikarya exceeded on day 40 that on day 5 by about 85%, whereas the intensity of GDH staining in granule cell bodies and in the molecular layer rose from postnatal day 5 to day 40 up to 325% and 400%, respectively. Due to the parallelism with the onset of aminoacidergic transmission processes, the results are interpreted as indicating the participation of GDH in the metabolism both of transmitter glutamate and of gamma-aminobutyric acid (GABA). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
