前列腺癌患者血清PSA及相关参数检测结果分析

目的：寻找前列腺癌适宜的血清学诊断标志物。方法：测定良性前列腺增生和前列腺癌患者血清游离PSA、总PSA，并计算PSAD、FPSA／TPSA、PSA／TPSA／PSAD等。结果：将PSA值分为0～、4μg／L～、10μg／L～和20μg／L～四个范围，BPH组构成比为39．06％、28．13％、25％和7．81％，而PCA组构成比为10．71％、17．86％、28．57％和42．86％，差异具有显著性（P〈0．01）；与BPH组患者相比较，PCA组患者PSA和PSAD检测值升高，FPSA／TPSA和PSA／TPSA／PSAD降低，差异均具显著性（P〈0．01）；当4ug／L≤PSA≤10ug／L时，PCA和BPH患者的PSA检测值差异无统计学意义（P〉0．05），但PCA组FPSA／TPSA和PSA／TPSA／PSAD低于BPH组，差异均具有显著性（P〈0．01）；当PSA〉20μg／L时，两组患者PSA、PSAD、FPSA／TPSA的差异均无统计学意义（P〉0．05），PCA患者仅PSA／TPSA／PsAD低于BPH患者，且差异具有显著性（P〈0．01）。结论：用PSA、PSAD、FPSA／TPSA诊断前列腺癌均具有一定局限性，PSA／TPSA／PSAD可能是诊断前列腺癌最适宜的血清学标志物。

Detection of prostate specific antigen and its relevant parameters in sera from patients with prostate cancer

Objective:To explore appropriate serological marker for diagnosis of prostate cancer.Methods:The levels of free prostate specific antigen(PSA),total PSA were detected in patients with benign prostatic hyperplasia(BPH) or prostate cancer(PCA),and prostate specific antigen density(PSAD),FPSA/TPSA and PSA/TPSA/PSAD were calculated.Results: The detected PSA values were divided into 0-,4ug/L-,10ug/L-and 20ug/L-four areas,the constitute ratios were 39.06%,28.13%,25% and 7.81% in patients with BPH,and they were 10.71%,17.86%,28.57%,42.86% in PCA,which were significant difference(P<0.01);Compared with the patients with BPH,the levels of PSA and PSAD increased,but the ratio of FPSA/TPSA and PSA/TPSA/PSAD decreased significantly(P<0.01);when the levels PSA between 4ug/L and 101-tg/L,no significant difference was observed in PSA values between PCA and BPH patients(P>0.05),but the ratio of FPSA/TPSA and PSA/TPSA/PSAD were both lower than those in BPH(P<0.01);when PSA values were 20 g/L or more,there was no difference in the levels of PSA and PSAD and the ratio FPSA to TPSA between the two groups,only the ratio of PSA/TPSA/PSAD was lower in PCA group than that in BPH(P<0.01).Conclusions: There are some limitations and shortcoming using PSA,PSAD and FPSA/TPSA in diagnosis of PCA, and PSA/TPSA/PSAD maybe the most appropriate serological marker for diagnosis of PCA.