正常成人脑部皮层下灰质结构的3D pc-ASL灌注成像的可重复性

目的 研究正常成人脑部皮层下灰质结构3D假连续快速自旋回波动脉自旋标记(3D pc-ASL)灌注的可重复性.方法 对8例健康成年人进行脑部3D pc-ASL序列及3D结构像扫描,同一时间间隔一周后再次进行扫描.对3D结构像进行皮层下灰质结构(壳核、苍白球、尾状核、丘脑、杏仁核、海马)分割,并将3D pc-ASL进行计算生成脑血流(CBF)图,基于分割后的图像及CBF图进行皮层下灰质结构CBF值提取.对于两次测量结果采用组内相关系数(ICC)及Bland-Altman图分析.结果 皮层下灰质结构的ICC值为0.80-0.93,均值为0.88±0.04.Bland-Altman图形分析证实所有皮层下灰质结构对应的点均位于95％一致性界限内.结论 3D pc-ASL是一个可靠的评估脑部皮层下灰质核团灌注的序列.

Test-retest reliability of 3D spiral fast-spin-echo pseudo-continuous arterial spin labeling for cerebral perfusion imaging of subcortical gray matter in healthy adults

Objective To evaluate the test-retest reliability of 3D spiral fast-spin-echo (FSE) pseudo-continuous arterial spin labeling (3D pc-ASL) for cerebral perfusion imaging of the subcortical gray matter in healthy adults in resting state.Methods 3D spiral FSE ASL and 3D T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequences were used for cerebral perfusion imaging in 8 healthy adult subjects,and a repeat imaging examination was performed after one week.The subcortical gray matter structures including the putamen,globus pallidus,caudate nucleus,thalamus,amygdala and hippocampus were segmented on the brain structural 3D images to generate the cerebral blood flow (CBF) map.The CBF value was extracted based on the segmented images and the CBF maps.The reliability and reproducibility of the measurements were evaluated using the intradass correlation coefficient (ICC) and Bland-Altman plot.Results The mean ICC value of the subcortical gray matter structures was 0.88±0.04 (range,0.80-0.93).The Bland-Altman plot analysis demonstrated that the differences between the two measurements at all the points corresponding to the subcortical gray matter structures were within 95％ CI of the limits of agreement.Conclusion 3D spiral FSE pseudo-continuous ASL is a reliable method for assessing the perfusion of the cerebral subcortical gray matter structures.