腔镜与开放手术在甲状腺近全切除术后引流量与全身创伤反应的对比

目的 探讨在双侧甲状腺近全切除术中,腔镜手术(胸乳入路腔镜甲状腺手术)与开放手术(传统颈部切口甲状腺手术)在术后引流量、全身创伤反应方面的差异,为选择合适的手术方式提供依据.方法 采用前瞻性临床对照研究,将80例初次行双侧甲状腺近全切除术的患者根据手术方式将其分为腔镜手术组(A组)和开放手术组(B组)各40例,分别统计术后引流液总量、术后拔管天数、术后每天引流量,术后第1天引流液甘油三酯(TG)、总蛋白(TP)含量,术前与术后第1天静脉血白细胞介素-6 (IL-6)、超敏C反应蛋白(HS-CRP)、α1-酸性糖蛋白(AAG)、铜蓝蛋白(CER)、触珠蛋白(HPT)含量,对比分析两组间上述指标的差异及变化规律.结果 A组平均术后引流液总量比B组显著增多(P=0.000),平均术后拔管天数比B组显著延长(P=0.000);A组术后每天平均引流量同期均比B组多(P=0.000),二者每天引流量变化趋势均为逐渐下降.两组术后第1天引流液中甘油三酯、总蛋白含量比较均无显著差异性(P=0.429,P=0.324).在A组或B组中,术后第1天静脉血中α1-酸性糖蛋白、铜蓝蛋白、触珠蛋白含量各自与术前比较均无显著差异性(P>0.05);而术后第1天静脉血中白细胞介素-6、超敏C反应蛋白含量与术前比较均有显著差异性(P=0.000).A组术后第1天血清白细胞介素-6、超敏C反应蛋白含量与B组比较均无显著差异性(P=0.054,P=0.066).结论 在双侧甲状腺近全切除手术中,与开放手术相比较,尽管腔镜手术术后引流量增多、拔管时间延长,但是并不增加全身的创伤反应程度.因此,对于有颈部无瘢痕美容要求的患者,腔镜手术可作为常规选择手术方式之一.

Comparison of postoperative drainage and systemic trauma response after endoscopic and traditional near total thyroidectomy

Objective To investigate the difference of postoperative drainage and systemic trauma response between endoscopic and traditional near total thyroidectomy to provide the basis for selecting appropriate operative methods. Methods In this prospective clinical controlled study,80 patientsscheduled for near total bilateral thyroidectomy for the first time were divided equally into endoscopic surgery group (group A) and open surgery group (group B). The total drainage volume after operation, postoperative extubation time, and postoperative daily drainage volume were recorded after the operation. The contents of triglyceride (TG) and total protein (TP) were determined in the postoperative drainage fluid onthe first day. The levels of interleukin-6 (IL-6), high-sensitive C reactive protein (HS-CRP), alpha 1-acid glycoprotein (AAG), ceruloplasmin (CER) and haptoglobin (HPT) in venous blood were tested before the operation and on the first day after surgery. Results Compared with those in group B, the postoperative drainage volumein group Aincreased significantly (P=0.000) and the postoperative extubation time was significantly prolonged (P=0.000); the mean postoperative daily drainage volume was significantly larger ingroup A than in group B (P=0.000) and tended to decrease with time in both groups. There was no significant difference in the content of triglycerideortotal protein in the drainage fluid between the two groups on the first day after operation(P=0.429 and 0.324,respectively).In both groups,the contents of AAG,ceruloplasmin and haptoglobin on the first postoperative day were all similar with those measurement before operation(P>0.05),but significant variations occurred in the levels of IL-6 and HS-CRP on the first postoperative day (P=0.000). The serum levels of IL-6 or HS-CRP did not differ significantly between the two groups on the first day after operation(P=0.054 and 0.066,respectively).Conclusion Compared with open surgery, endoscopic near total bilateral thyroidectomyis associated with an increased the volume of postoperative drainage and a prolonged time of extubationbut not an increased systemic trauma response. Therefore, endoscopic surgery can serve as one of the routine options for patients who are concerned with neckscars resulting from open surgeries.