| 骨髓基质细胞/藻酸盐凝胶复合修复骨缺损的研究 |
| |
| 引用本文： | 李光辉,夏仁云,陈超. 骨髓基质细胞/藻酸盐凝胶复合修复骨缺损的研究[J]. 中华实验外科杂志, 2003, 20(11): 1031-1032,F003 |
| |
| 作者姓名： | 李光辉 夏仁云 陈超 |
| |
| 作者单位： | 430030,武汉,华中科技大学同济医学院附属同济医院骨科 |
| |
| 摘 要： | 目的 探讨骨髓基质细胞(BMSCS)复合藻酸盐凝胶修复骨缺损的效果。方法 将体外培养的骨髓基质细胞与藻酸盐凝胶复合，实验组、对照组和空白组分别经皮注射BMSCS／藻酸盐凝胶复合物、BMSCS悬液和生理盐水，比较3者修复骨缺损的疗效。结果实验组术后12周时全部骨愈合，对照组有2例未愈合，空白组无1例愈合。结论 BMSCS／藻酸盐凝胶复合物有明显促进骨缺损修复的作用。
|
| 关 键 词： | 骨髓基质细胞 藻酸盐凝胶 修复 骨缺损 复合物 动物模型 |
Calcium alginate hydrogel bone marrow stromel cells composite to repair bone defects |
| |
| LI Guanghui,XIA Renyun,CHEN Chao. Calcium alginate hydrogel bone marrow stromel cells composite to repair bone defects[J]. Chinese Journal of Experimental Surgery, 2003, 20(11): 1031-1032,F003 |
| |
| Authors: | LI Guanghui XIA Renyun CHEN Chao |
| |
| Affiliation: | LI Guanghui,XIA Renyun,CHEN Chao.Department of Orthopaedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
| |
| Abstract: | Objective To investigate the efficacy of alginate hydrogel bone marrow stromel cells (BMSCS) composite in repairing bony defects.Methods BMSCS cultured in vitro were mixed with calcium gluconate.The mixture was injected into the bone defects as experimental group and the single BMSCS were injected as control group.Results All specimens had complete bone union at 12th week in experimental group,while there were two cases of bone non -union in the control group.Conclusion The composite can effectively promote the healing of bone defects. |
| |
| Keywords: | Bone defect Bone marrow Stromel cell |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
